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Epilepsie

Crize epileptice și managementul lor.

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StudiuEpilepsieÎncredere bună19.06.2026

Hematological Adverse Reactions in Epilepsy Patients: Monotherapy versus Polytherapy Comparison

This hospital-based study compared hematological parameters in 200 epilepsy patients receiving either single or multiple anti-seizure medications, finding that polytherapy was associated with different hematological profiles including variations in neutrophil counts, hemoglobin, and platelet indices. Certain blood parameters showed modest discriminatory ability for predicting treatment patterns, suggesting medication regimens may influence hematological outcomes in epilepsy.

StudiuEpilepsieÎncredere înaltă19.06.2026

Longitudinal Australian trends in valproate initiation among women of reproductive age and concurrent prescription contraceptive use

This population-based cohort study analyzed Australian prescription data from 2013-2021 and found that valproate initiation in women aged 15-49 years declined substantially while alternative anti-seizure medications increased, reflecting heightened awareness of reproductive risks. Although contraceptive coverage among valproate-treated women improved, nearly 70% had no prescription contraception coverage in 2021, indicating ongoing gaps in pregnancy prevention strategies.

StudiuEpilepsieÎncredere bună19.06.2026

Effectiveness of China Acute Seizure Action Plan for Improving Caregiver Management of Pediatric Epilepsy

A prospective study evaluated a context-adapted seizure action plan (CASAP) in 313 Chinese caregivers of children with epilepsy, showing significant improvements in knowledge and emergency management practices following a 6-month intervention. Digital tool integration and caregiver education level were identified as factors influencing intervention effectiveness, though attitude changes required longer-term follow-up.

StudiuEpilepsieÎncredere bună19.06.2026

Visually Enhanced Mental Simulation for Improving Seizure Response Skills and Attitudes Toward Epilepsy in Teacher Candidates

This study evaluated whether Visually Enhanced Mental Simulation (VEMS) training improves pre-service teachers' ability to respond to epileptic seizures and their attitudes toward epilepsy. Results showed significant improvements in both seizure-response performance and positive attitudes following the simulation-based intervention.

StudiuEpilepsieÎncredere bună19.06.2026

Comparing normative and ipsative cognitive phenotype classification methods in frontal lobe epilepsy

This study compared two approaches for classifying cognitive phenotypes in 100 adults with frontal lobe epilepsy using the IC-CoDE framework: normative (performance relative to peers) and ipsative (performance relative to individual baseline). The ipsative method classified more patients as cognitively intact, with poor agreement between approaches, and findings suggest anti-seizure medication burden and younger age may be associated with cognitive impairment patterns.

StudiuEpilepsieÎncredere înaltă19.06.2026

Management of Ring Chromosome 20 Syndrome: Clinical Consensus and Treatment Recommendations

Ring chromosome 20 is a rare genetic disorder causing developmental and epileptic encephalopathy, characterized by drug-resistant seizures that significantly impact quality of life. A taskforce of epilepsy specialists and caregivers reviewed available literature and provided consensus recommendations for multidisciplinary management, including genetic counseling, acknowledgment of treatment resistance, and monitoring for non-convulsive status epilepticus.

StudiuEpilepsieÎncredere bună19.06.2026

Case Report: Diagnostic Challenge Between Epileptic Seizure and Tetany in Albright Hereditary Osteodystrophy

This case report examines the clinical difficulty in distinguishing between epileptic seizures and tetany (muscular contractions from hypocalcemia) in patients with Albright hereditary osteodystrophy, a genetic disorder affecting bone development and hormone responsiveness. The report illustrates how similar clinical presentations require careful diagnostic evaluation to differentiate between neurological and metabolic causes of seizure-like symptoms.

StudiuEpilepsieÎncredere înaltă19.06.2026

Correlation between stigma, social alienation, and quality of life in people with epilepsy

This study examined 127 adults with epilepsy to investigate the relationship between stigma, social alienation, and quality of life using validated assessment scales and rigorous statistical methods. Results indicate positive correlations between stigma and quality of life outcomes, contributing to understanding of psychosocial factors affecting epilepsy management.

StudiuEpilepsieÎncredere bună19.06.2026

Brief semiological training improves neurology residents' ability to distinguish functional/dissociative seizures from epileptic seizures

A study of 45 neurology residents evaluated whether 15 minutes of training on clinical signs of functional/dissociative seizures (FDS) would improve their ability to differentiate FDS from epileptic seizures using video recordings. After training, diagnostic accuracy improved significantly from 77% to 89%, suggesting brief educational intervention on semiological features can effectively enhance clinical recognition of functional seizures.

StudiuEpilepsieÎncredere înaltă19.06.2026

Artificial Intelligence and Machine Learning in Pediatric Epilepsy: A Systematic Review

This systematic review evaluates AI-based tools for interpreting clinical data in pediatric epilepsy, finding that convolutional neural networks and support vector machines achieve diagnostic accuracy exceeding 90% for EEG analysis and seizure detection. While results are promising, the authors note that current validation is limited by small cohort sizes and emphasize the need for large-scale, multicenter studies before clinical implementation.

StudiuEpilepsieÎncredere bună19.06.2026

Management of First Non-febrile Convulsive Seizure in Pediatric Emergency Department: Retrospective Study 2015-2021

A retrospective analysis of 167 children presenting to a pediatric emergency department with first non-febrile convulsive seizures, categorizing cases as epileptic seizures (59.3%), non-epileptic paroxysmal events (38.3%), or acute symptomatic seizures (2.4%). The study evaluated clinical examination findings and semiological features to develop a practical management algorithm for distinguishing seizure types in pediatric emergency settings.

StudiuEpilepsieÎncredere înaltă19.06.2026

Listening across frequencies: Capturing seizures of all patients to advance antiseizure medication development

The paper critiques the traditional requirement of ≥4 seizures per month for epilepsy trial enrollment, noting this threshold excludes many patients as improved treatments have reduced baseline seizure burden. The authors propose alternative time-to-event trial designs that enable broader patient inclusion while maintaining rigor, alongside integration of cognitive outcome measures alongside seizure control assessments.

StudiuEpilepsieÎncredere înaltă19.06.2026

Modelling precise responses to anti-seizure medication using brain organoids carrying SCN2A-GoF and SCN2A-LoF mutations

This study uses brain organoid models to investigate how gain-of-function and loss-of-function SCN2A mutations affect response to anti-seizure medications, potentially enabling personalized treatment approaches for epilepsy patients. The research applies modern neurodevelopmental modeling techniques to understand drug responsiveness at the cellular level.

StudiuEpilepsieÎncredere înaltă19.06.2026

Ganglioglioma surgery and anti-seizure medication outcomes: A nationwide Swedish registry cohort study

This registry-linked study of 144 Swedish patients with surgically treated ganglioglioma examined anti-seizure medication (ASM) discontinuation rates following surgery. Five years post-surgery, 36% of adults and 59% of children had discontinued ASMs, with no significant difference between those treated in specialized epilepsy surgery programs versus other surgical settings.

StudiuEpilepsieÎncredere bună19.06.2026

TFFBN-HDLF: Hybrid Deep Learning Framework for Epileptic Seizure Detection Using Time-Frequency Functional Brain Networks

This study presents a hybrid deep learning framework combining time-frequency functional brain networks with CNN and Transformer modules to improve epilepsy seizure detection in elderly patients from EEG signals. The method uses Pearson correlation and phase lag index to construct brain networks that capture synchronous neural interactions, converting complex EEG data into clinically useful features for automated seizure detection.

StudiuEpilepsieÎncredere înaltă19.06.2026

Understanding Misdiagnosis in Pediatric Epilepsy: A Prospective Analysis of Predictors and Patterns

This prospective study of 438 children referred with epilepsy diagnoses found that 12.1% were actually misdiagnosed, with migraine, functional seizures, and movement disorders being the true conditions. Age ≥10 years and urban residency were identified as independent predictors of misdiagnosis, highlighting the importance of expert diagnostic validation in pediatric neurology.

StudiuEpilepsieÎncredere înaltă19.06.2026

Self-Supervised Learning With Adaptive Graph Modeling for EEG-Based Epileptic Seizure Classification

This paper presents ASGPF, a self-supervised learning framework that uses graph neural networks and gated recurrent units to classify epileptic seizures from EEG signals with improved accuracy even with limited labeled data. The method achieved weighted F1-scores of 83.8% on four-class and 73.5% on eight-class seizure classification tasks on the TUSZ dataset, demonstrating robustness to data scarcity.