Dependențe de substanțe și comportamentale.
135 de articoleA smartphone-based treatment program using contingency management (digital rewards) has received NIDA funding to help pregnant individuals quit smoking. This behavioral intervention approach is grounded in established addiction treatment research and addresses a critical public health need during pregnancy.
An FDA-approved rheumatoid arthritis drug that blocks IL-6 receptors significantly reduced excessive alcohol consumption in alcohol-dependent female mice by suppressing neuroinflammation in the central amygdala. This mechanism aligns with elevated IL-6 expression observed in postmortem brain tissue from individuals with alcohol use disorder, suggesting a potential therapeutic target.
This neuroimaging study compared brain structural connectivity in 25 individuals with gambling disorder versus 28 healthy controls using diffusion tensor imaging and probabilistic tractography. The gambling disorder group showed increased striatal connectivity but reduced frontal lobe connectivity and fewer neural hubs, suggesting impaired network integration related to risk-taking control.
This retrospective cohort study analyzed medication prescribing patterns for 101 adolescents and young adults (mean age 18.5 years) with opioid use disorder and co-occurring psychiatric conditions, finding high rates of polypharmacy (79.2%), medication switching (91.2%), and treatment non-persistence. Depression, anxiety disorders, and ADHD were the most common psychiatric comorbidities, with non-persistence particularly prevalent in depression (63.2%) and bipolar disorder (66.7%).
This study compared reward processing between adolescents with Internet Gaming Disorder (IGD) and recreational game users using established behavioral tasks measuring sensitivity to monetary and social rewards. Adolescents with IGD showed faster reaction times to combined rewards but no differences in response to individual reward types, suggesting reward processing specificity related to stimulus complexity in gaming disorder.
Gaming disorder, recognized by WHO and APA as a behavioral addiction, affects individuals who experience significant daily functioning impairment from excessive gaming. While moderate gaming offers benefits like stress relief and cognitive improvement, addiction is linked to psychological disorders requiring long-term treatment including cognitive behavioral therapy, making prevention efforts at government, developer, and household levels essential.
This research investigates theta burst stimulation, a neuromodulation technique, as a potential treatment for gambling disorder by measuring changes in craving intensity and relevant biological markers. The study examines whether this brain stimulation approach can reduce gambling cravings and identify associated neurobiological changes in affected patients.
This study examined how personality dimensions and impulsivity traits relate to problematic internet usage among 1,144 online MMORPG and poker players using validated psychological instruments. Neuroticism, negative urgency, positive urgency, and sensation seeking were significantly associated with higher addiction scores, while extraversion showed a protective effect, with similar patterns observed across both gaming groups.
This Swedish register-based cohort study followed individuals from 1973–2018 to examine whether children of parents hospitalized for alcohol use disorder had elevated risks of various substance use disorders (alcohol, opioids, cannabis, stimulants, sedatives, hallucinogens, solvents) compared to controls. Children with severely affected parents showed significantly higher risks across all substance categories, with particularly elevated hazard ratios for other stimulants (5.33×) and volatile solvents (4.95×), suggesting both general and substance-specific genetic/environmental vulnerability pa
This work examines the intersection of gambling disorder and legal accountability within the Brazilian justice system, analyzing how behavioral addiction affects criminal responsibility determinations. It addresses forensic and legal implications of recognizing gambling disorder as a behavioral addiction in criminal proceedings.
This study translated and adapted the Online Gambling Disorder Questionnaire (OGD-Q) for Brazilian Portuguese, examining its psychometric properties across 298 participants. The instrument demonstrated strong internal consistency (Cronbach's alpha 0.92) and significant correlations with depression, anxiety, stress, and online gaming behavior, supporting its validity as a screening tool for problematic online gambling.
This retrospective study evaluated the clinical application of PEth, a blood biomarker detecting alcohol use in the prior 28 days, across 2,472 kidney transplant candidates at three medical centers (2020-2024). Among participants, 9.4% tested positive for PEth, with most indicating moderate alcohol consumption, informing transplant candidacy decisions and substance use disorder management.
This systematic review synthesizes 30 peer-reviewed studies on gambling disorder (GD) within couple relationships, examining its behavioral addiction features (craving, tolerance, withdrawal) and complex etiology. Research highlights how dysfunctional relational dynamics perpetuate GD, with studies documenting impacts on partners, links to domestic violence, and bidirectional relationships between couple dynamics and gambling behaviors.
This neuroimaging study compared brain activation patterns during reward conditioning and extinction learning between 25 individuals with internet gaming disorder, 23 at-risk gamers, and 35 controls. Findings show that problematic gamers display reduced sensitivity to non-gaming rewards in reward-processing brain regions and show altered extinction learning patterns, supporting the hypothesis that gaming disorder shares neurobiological mechanisms with substance addictions.
This academic work examines methodological issues and systematic biases in the instruments used to assess gaming disorder. The study contributes to improving diagnostic accuracy and reliability of behavioral addiction measurement tools.
This retrospective study of 633 patients with alcohol or substance use disorders found that folate deficiency varies significantly by substance type, with methamphetamine users showing the lowest folate levels and highest folate deficiency rates. Alcohol, methamphetamine, and opioid users had significantly higher folate deficiency compared to cannabis users, highlighting the importance of nutritional assessment in substance use disorder treatment.
This clinical case explores the relationship between gambling disorder and elevated suicide risk, highlighting the severity of behavioral addiction and associated mental health complications. The presentation documents a real patient scenario illustrating how gambling addiction can co-occur with suicidal ideation and the importance of integrated psychiatric assessment.
This editorial examines the current state of scientific understanding regarding how addiction affects brain structure and function. It reviews established research methods and discusses emerging perspectives on studying addiction neurobiology.
