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StudiuTraumatisme cranio-cerebraleÎncredere înaltă21.06.2026

Epidemiology of Head Injury and Associations with Clinical and Neuropsychological Outcomes in Older American Indians: Strong Heart Study Data

This epidemiological study examined head injury prevalence and outcomes in 818 older American Indians (mean age 73) from the Strong Heart Study, finding 40% reported prior head injury with 4-6% experiencing loss of consciousness exceeding 20 minutes. Those with previous head injury demonstrated significantly worse depressive symptoms, quality of life, fatigue, and social functioning compared to those without injury history, with male sex and prior stroke identified as independent risk factors.

StudiuTraumatisme cranio-cerebraleÎncredere bună21.06.2026

Convergence insufficiency as a predictor of poor prognosis after acute mild traumatic brain injury

This prospective study evaluated the feasibility of screening for convergence insufficiency (CI) symptoms in emergency department patients with mild traumatic brain injury using the Convergence Insufficiency Symptom Survey (CISS). Higher CISS scores were associated with adverse outcomes including post-concussive symptoms and hospital admission, suggesting oculomotor assessment may help identify patients at risk for poor recovery after mTBI.

StudiuTraumatisme cranio-cerebraleÎncredere bună21.06.2026

H4R antagonist JNJ-7777120 reduces traumatic brain injury damage via ERK1/2/NF-κB pathway inhibition in rats

This preclinical study demonstrates that JNJ-7777120, a histamine H4 receptor antagonist, improves motor and sensory function in rats with mild traumatic brain injury by reducing neuroinflammation, apoptosis, and oxidative stress. The neuroprotective effects occur through blockade of ERK1/2/NF-κB signaling pathways.

StudiuTraumatisme cranio-cerebraleÎncredere înaltă21.06.2026

Neurobehavioral Symptoms in Spanish-Speaking Individuals With Subconcussive Head Injuries

This cross-sectional study examined 709 Spanish-speaking adults (aged 18–65) to determine whether repeated head/neck injuries without loss of consciousness (subconcussive exposures) correlate with neurobehavioral symptoms. Results showed significant effects of both lifetime injury history and frequency of subconcussive exposure on symptom severity measured by the Neurobehavioral Symptom Inventory.

StudiuTraumatisme cranio-cerebraleÎncredere bună21.06.2026

Repetitive injury causes Alzheimer's disease-like phenotypes via reactivation of HSV-1 in a 3D human brain tissue model

This study demonstrates that repetitive traumatic brain injury can trigger reactivation of herpes simplex virus-1 (HSV-1) in human brain tissue, leading to pathological features characteristic of Alzheimer's disease. The research was conducted using advanced 3D brain tissue models, providing insights into potential mechanisms linking TBI to neurodegenerative disease risk.