Safinamide Effects on Sleep Architecture in Motor Fluctuating Parkinson's Disease: A Polysomnographic Study Compared to Rasagiline
A prospective study of 45 Parkinson's disease patients with sleep disturbances compared safinamide and rasagiline, two monoamine oxidase-B inhibitors. Safinamide showed superior sleep improvements including increased deep sleep (N3), better sleep efficiency, and reduced periodic limb movements, with significant improvements on sleep quality scales, while rasagiline showed minimal sleep benefit despite motor symptom improvement in both groups.