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This multicenter study developed and piloted a Down syndrome-specific musculoskeletal screening tool to identify inflammatory arthritis (DA) in individuals with DS, finding a 2% confirmed diagnosis rate among positive screens. The tool is simple and feasible for clinical use, with symptoms of joint swelling, redness, warmth, and stiffness being most predictive of DA.
This retrospective study evaluated surgical outcomes for strabismus correction in 37 Down syndrome patients across esotropia, fourth nerve palsy, and mixed strabismus groups. Overall surgical success rates ranged from 40-86% depending on strabismus type, with 73% of cases achieving correction with a single procedure.
This study develops Down syndrome-specific percentile curves for fine motor and visual motor integration skills in children aged birth to 6 years using the PDMS-2 assessment. While fine motor development is delayed compared to typical development, the curves enable clinicians to identify children requiring intervention and help parents understand their child's developmental trajectory.
Researchers developed and validated a 25-item caregiver-reported health measure for individuals with Down syndrome aged 0-21 years, consisting of 3 domains and 7 scales with strong psychometric properties (Cronbach's α: 0.77-0.96, ICC: 0.71-0.94). The measure demonstrated construct validity, test-retest reliability, and ability to differentiate between Down syndrome and autism spectrum disorder in a national sample of 542 caregivers.
Study examining abnormal high-frequency brain oscillations occurring during sleep in individuals with Down syndrome. Research likely aims to characterize neurophysiological differences and their potential relationship to cognitive and developmental outcomes.