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This review examines how biological aging accelerates disease progression in multiple sclerosis, particularly in progressive forms resistant to current treatments. Evidence from animal models and clinical biomarkers (telomere length, DNA methylation) suggests MS patients experience accelerated aging, opening potential avenues for senotherapy-based interventions targeting aging-related pathways.
This study examined cardiovascular autonomic dysfunction in women with relapsing-remitting MS by measuring beat-to-beat blood pressure variability and sympathetic baroreflex sensitivity compared to healthy controls. The research hypothesized that reduced sympathetic control in MS patients leads to impaired blood pressure regulation, using continuous electrocardiogram and blood pressure monitoring along with muscle sympathetic nerve activity recordings.
This review examines autophagy—a cellular degradation process—as a double-edged sword in multiple sclerosis, showing both protective effects (reducing oxidative stress and inflammation) and harmful effects (promoting demyelination when over-activated). The paper discusses how autophagy modulates immune cell activation and oligodendrocyte function, suggesting selective autophagy modulation could be a therapeutic strategy depending on disease context.
This cross-sectional study used magnetic resonance fingerprinting (MRF) to measure T1 and T2 relaxation times in brain tissue of healthy controls, relapsing-remitting MS patients, and secondary progressive MS patients, finding progressive increases in relaxation times across disease stages. The findings suggest MRF may be useful for quantitative tissue characterization and differentiation between MS disease subtypes and disease progression.
This systematic review examines scientific evidence on neuropsychological interventions targeting cognitive impairment in people with relapsing-remitting MS, a common disabling neurological disease in young adults. Analysis of 15 articles meeting rigorous inclusion criteria found that most cognitive rehabilitation programs demonstrated effectiveness, though methodological standardization remains lacking in this field.