Structural and Metabolic Correlates of Neuropsychological Profiles in Multiple System Atrophy and Parkinson's Disease
This comparative neuroimaging study examined cognitive impairment in 11 patients with multiple system atrophy with parkinsonism (MSA-P) and 11 with Parkinson's disease using neuropsychological testing, diffusion tensor imaging, and PET imaging. Findings showed MSA-P patients had greater executive dysfunction and higher depression/anxiety scores, with specific correlations between cognitive performance and frontostriatal white matter integrity and glucose metabolism in both conditions.