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StudiuAVC și AITÎncredere bună22.06.2026

Association of Thyroid Peroxidase Antibody with RNF213 p.R4810K Variant in Ischemic Stroke and Transient Ischemic Attack

This multicenter study of 2,090 stroke/TIA patients examined whether elevated thyroid peroxidase antibody (TPO-Ab) levels are associated with the RNF213 p.R4810K genetic variant, known to increase vasculopathy risk. Variant carriers showed significantly higher TPO-Ab levels and increased frequency of elevated antibody titers, suggesting TPO-Ab may act as a second hit in RNF213-related stroke pathogenesis.

StudiuAVC și AITÎncredere bună22.06.2026

Reader Response: Association of Alternative Anticoagulation Strategies and Outcomes in Patients With Ischemic Stroke on Direct Oral Anticoagulants

This peer commentary examines clinical outcomes associated with different anticoagulation approaches in patients experiencing ischemic stroke while taking direct oral anticoagulants (DOACs). The response contributes to evidence-based discussion on stroke management strategies in anticoagulated populations.

StudiuAVC și AITÎncredere înaltă22.06.2026

Individualized Interpretation of FLAIR Vessel Hyperintensity in Ischemic Stroke and Transient Ischemic Attack: A Systematic Review

This systematic review examines FLAIR vessel hyperintensity (FVH), an imaging finding reflecting critically slowed blood flow in large artery steno-occlusions, and its clinical significance for predicting prognosis, stroke severity, infarction volume, and functional outcomes in acute ischemic stroke and TIA. The authors address conflicting findings in the literature and propose key factors for individualizing clinical interpretation of this neuroimaging marker to guide clinical decision-making.

StudiuAVC și AITÎncredere înaltă22.06.2026

Cost-Effectiveness of CYP2C19 Genotype-Guided Antiplatelet Therapy for Acute Minor Ischemic Stroke and High-Risk TIA in China

A pharmacoeconomic study evaluated whether personalizing antiplatelet therapy based on CYP2C19 genetic testing (using cilostazol or ticagrelor) is cost-effective compared to standard clopidogrel plus aspirin treatment for minor stroke and high-risk transient ischemic attack in China. The analysis found genotype-guided strategies were cost-effective with incremental cost-effectiveness ratios below accepted thresholds, with robust results across sensitivity analyses.