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Sănătate mintală și neurodezvoltare

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StudiuADHDÎncredere bună25.06.2026

Efficacy and Safety of SPN-812 (Extended-Release Viloxazine) in Children and Adolescents with ADHD: A Systematic Review and Meta-Analysis

This meta-analysis of five randomized controlled trials involving 1,619 pediatric patients (ages 6-17) demonstrates that SPN-812 at doses of 100, 200, and 400 mg/day significantly improved ADHD symptoms compared to placebo on multiple validated rating scales. SPN-812 at 300 mg/day showed favorable safety profiles with no increased risk of serious adverse events like syncope, though higher doses were associated with increased somnolence and appetite suppression.

StudiuAutism + ADHDÎncredere bună24.06.2026

Effect of Prior Depression Diagnosis on Bipolar Disorder Outcomes: A Retrospective Cohort Study

This retrospective cohort study analyzed 5,595 Japanese patients newly diagnosed with bipolar disorder to examine whether a prior depression diagnosis and its duration affected psychiatric and all-cause hospitalization rates and mortality. Patients with prior depression history showed slightly lower all-cause hospitalization risk (HR=0.87), with duration of preceding depression (≥1 year vs <1 year) not significantly altering psychiatric hospitalization outcomes.

PresăADHDÎncredere bună23.06.2026

Ancient Brainstem Neurons Discovered to Control Attention

Researchers identified an evolutionarily conserved circuit of inhibitory neurons in the brainstem that regulates selective spatial attention. This discovery may enhance understanding of attention mechanisms relevant to conditions like ADHD.

StudiuAutism + ADHDÎncredere bună23.06.2026

Autism in Schizophrenia and Its Original Link to Self-Disorder: Returning a Borrowed Concept

This academic paper traces the historical origins of the term 'autism' coined by Eugen Bleuler in 1910 to describe schizophrenia, and how the concept was later borrowed to describe autism spectrum disorder, leading to diagnostic confusion. The authors argue that autistic features in schizophrenia differ fundamentally from autism spectrum disorder—rooted in self-disorder rather than developmental autism—and propose this distinction is crucial for accurate differential diagnosis and appropriate treatment.

StudiuAutism + ADHDÎncredere bună22.06.2026

Association Between Bipolar Disorder and Parkinson's Disease: A Review of Dopaminergic Mechanisms and Clinical Implications

This literature review examines the association between bipolar disorder and Parkinson's disease, focusing on their shared dopaminergic dysfunction in nigrostriatal and mesolimbic pathways. Recent analyses and meta-analyses show increased risk of developing Parkinson's disease in bipolar disorder patients, though differentiating idiopathic from medication-induced parkinsonism requires careful evaluation including DAT scans.