Arterial Input Function Dispersal on CT Perfusion Associated with Cerebral Small Vessel Disease in Stroke Patients
This retrospective study of 369 acute ischemic stroke/TIA patients found that prolonged arterial input function dispersal on computed tomography perfusion correlates with higher burden of cerebral small vessel disease markers including white matter hyperintensities and microbleeds. Each 1-second increase in dispersal independently predicted increased odds of severe small vessel disease, suggesting cardiac hemodynamic dysfunction contributes to microvascular pathology in stroke.