NeuroPsy InfoHub adună studii și articole verificate editorial despre sănătate mintală și afecțiuni neurologice — pentru pacienți, familii și specialiști.
Depression affects over one-third of Parkinson's disease patients with significant diagnostic challenges due to symptom overlap between the conditions. Treatment involves pharmacotherapy (SSRIs, SNRIs, tricyclics) and psychotherapy (CBT, interpersonal therapy) adapted for PD-specific vulnerabilities, though access to specialized mental health care remains limited.
This exploratory study investigated the feasibility of repeated neurofeedback sessions using implanted DBS systems in 8 Parkinson's disease patients, where real-time visual feedback of beta oscillations from the subthalamic nucleus allowed patients to attempt regulation of neural activity across three separate days. Results showed significant beta power reduction in sessions 1 and 3, with dopaminergic medication negatively impacting downregulation performance while DBS stimulation enhanced it.
This study examines structural changes in specific thalamic regions among patients with Parkinson's disease dementia using advanced neuroimaging analysis. Machine learning algorithms are applied to these volumetric measurements to develop predictive models for diagnosis and disease severity assessment.
GLP-1 receptor agonists, originally developed for diabetes and obesity, show neuroprotective properties in preclinical models of movement disorders by modulating neuroinflammation, oxidative stress, and protein aggregation. Clinical evidence is most advanced in Parkinson's disease, though early promise from exenatide and lixisenatide trials was not confirmed in larger phase III studies, with preliminary signals emerging in other movement disorders.
This PET neuroimaging study examined cholinergic terminal density in 16 patients with isolated REM sleep behavior disorder (iRBD, a prodromal stage of Parkinson's disease) compared to 12 Parkinson's patients and 18 controls. Both patient groups showed similar cortical cholinergic denervation (11-12% reduction) with distinct regional patterns, while iRBD showed associations between lower cholinergic uptake and impaired executive/visuospatial function.