Huntingtin Protein Levels Modulate Susceptibility to Spontaneous Seizures in FVB/N Mice
This study demonstrates that huntingtin protein levels affect the occurrence of a spontaneous seizure disorder in FVB/N mice, with reduced huntingtin increasing seizure frequency while overexpression prevents seizures entirely. The findings raise important considerations for huntingtin-lowering therapies being tested for Huntington disease, suggesting potential adverse effects on seizure susceptibility as a consequence of reduced wild-type huntingtin levels.