NeuroPsy InfoHub adună studii și articole verificate editorial despre sănătate mintală și afecțiuni neurologice — pentru pacienți, familii și specialiști.
This narrative review examines how precise phenotypic characterization of treatment-resistant depression (TRD) can improve clinical outcomes and guide therapeutic interventions. The authors analyze current definitional frameworks and evidence-based approaches to identifying and managing patients with depression that has not responded to standard pharmacological treatments.
This article examines how neuroinflammation contributes to depression through activation of immune pathways and cytokine signaling in the brain. It discusses identified biomarkers of neuroinflammation and explores anti-inflammatory therapeutic approaches as potential treatments for depressive disorders.
A New Zealand survey of 119 GPs and 62 midwives revealed significant variability in knowledge, attitudes, and practices regarding SSRI use during pregnancy, with midwives reporting greater discomfort (36% vs 11%) in managing perinatal depression. Clinical management recommendations varied considerably across respondents, and patient counseling and written information provision were frequently inadequate despite guidelines supporting SSRIs as first-line treatment when psychosocial interventions fail.
This study protocol examines gut microbiota composition differences between Malaysian patients with major depressive disorder (in monotherapy and polypharmacy groups) and healthy controls using 16S rRNA gene sequencing. The research aims to fill knowledge gaps about how microbial metabolites influence mood and behavior in the Malaysian population.
This health services research study analyzed treatment patterns, healthcare utilization, and costs among commercially insured US patients with newly diagnosed major depressive disorder, comparing pharmacologic, nonpharmacologic, combination, and no treatment approaches. The study examined associations between patient/provider characteristics and treatment selection while measuring healthcare resource use and economic outcomes over a 2-year follow-up period.