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This review examines whether Alzheimer's disease and major depressive disorder share common pathophysiological mechanisms, particularly through reduced TGF-β1 cytokine levels and amyloid-beta accumulation. The authors discuss emerging evidence that certain antidepressants (SSRIs, SNRIs, ketamine) may have neuroprotective effects, though they note the evidence remains inconsistent and potentially adverse effects require further investigation.

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This integrative review examines CCR5's role as a regulator of neuroinflammation and cognitive function across multiple neurodegenerative and acquired neurological conditions including Alzheimer's disease, Parkinson's disease, MS, TBI, and stroke. Both genetic and pharmacologic CCR5 inhibition show potential to reduce neuroinflammation and preserve cognitive function, though some evidence suggests context-dependent protective roles in certain conditions, highlighting therapeutic complexity.

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Self-Regulation Domains in Autism, Down Syndrome, and Williams Syndrome: Transdiagnostic vs. Condition-Specific Patterns

This empirical study examined regulatory control across autism, Down syndrome, Williams syndrome, and neurotypical development in 233 children aged 5–13 using parent-report questionnaires assessing cognitive, emotional, social, and sensory regulation. Findings revealed both shared regulatory challenges across neurodiverse groups and condition-specific differences, with cluster analyses suggesting that regulatory profiles rather than diagnostic labels better predict support needs.