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This multi-center Chinese cohort study of 1,013 women with epilepsy examined how folic acid supplementation affects pregnancy outcomes, finding that FA use in ASM-exposed pregnancies reduced risks of adverse composite outcomes and fetal death. Supplementation at ≥0.4 mg/day provided protection, with dose-response relationships analyzed using appropriate statistical models.
A prospective study of 40 children on levetiracetam monotherapy found no significant changes in thyroid hormone levels or autoimmune markers over 6 months of treatment. Although thyroid volume standard deviation scores decreased slightly, absolute thyroid volume and thyroid function remained stable, suggesting levetiracetam does not adversely affect thyroid health in the short term.
This study proposes a machine learning framework combining Hjorth parameters extracted from time and time-frequency domains with deep neural networks (CNN, BiLSTM, and attention mechanisms) to classify epileptic seizure stages. The approach achieved 98.4% accuracy for binary classification and 85.4% for five-class discrimination on the Bonn EEG dataset using rigorous cross-validation.
This hospital-based study compared hematological parameters in 200 epilepsy patients receiving either single or multiple anti-seizure medications, finding that polytherapy was associated with different hematological profiles including variations in neutrophil counts, hemoglobin, and platelet indices. Certain blood parameters showed modest discriminatory ability for predicting treatment patterns, suggesting medication regimens may influence hematological outcomes in epilepsy.
This population-based cohort study analyzed Australian prescription data from 2013-2021 and found that valproate initiation in women aged 15-49 years declined substantially while alternative anti-seizure medications increased, reflecting heightened awareness of reproductive risks. Although contraceptive coverage among valproate-treated women improved, nearly 70% had no prescription contraception coverage in 2021, indicating ongoing gaps in pregnancy prevention strategies.
