Folic acid supplementation and prevention of adverse offspring outcomes among women with epilepsy: An observational study

This multi-center Chinese cohort study of 1,013 women with epilepsy examined how folic acid supplementation affects pregnancy outcomes, finding that FA use in ASM-exposed pregnancies reduced risks of adverse composite outcomes and fetal death. Supplementation at ≥0.4 mg/day provided protection, with dose-response relationships analyzed using appropriate statistical models.