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This study compared EEG recordings with and without hyperventilation to assess their role in detecting epileptiform abnormalities across 659 patients. Hyperventilation, longer recording duration, and sleep deprivation all increased the likelihood of detecting epileptiform discharges, with hyperventilation showing particular benefit in children but not adults.
This study proposes a causal attention network (CANet) that combines dilated causal convolution and attention mechanisms to predict seizures during extended preictal periods (up to 2 hours before onset). Testing on standard epilepsy datasets showed high sensitivity (92-100%) and low false alarm rates, with average prediction times exceeding 90 minutes, potentially allowing sufficient time for therapeutic intervention.
A case report documents successful breastfeeding by a mother with drug-resistant epilepsy treated with eslicarbazepine acetate, with measured infant serum drug levels at 9.1% and 7.5% of maternal concentration and no adverse effects at 13 months follow-up. The authors conclude that breastfeeding may be considered under clinical supervision for healthy term infants of mothers on eslicarbazepine monotherapy, while noting that safety data remain limited.
This case-control study of 132 epilepsy patients and 131 controls found significantly lower serum subfatin levels in epilepsy patients compared to controls, with ROC analysis showing good diagnostic discriminatory power (AUC 0.84). The authors propose subfatin as a promising biomarker that may reflect neuroinflammatory processes in epileptogenesis, with potential diagnostic and prognostic utility.
This study examined how diazepam nasal spray, an FDA-approved rescue medication for seizure clusters in children aged 2-5 years, affected the time interval between cluster episodes. Results showed the mean interval between seizure clusters approximately doubled over the treatment period, suggesting improved seizure control with continued use of the medication.