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Multiple Sclerosis Agents: Disease-Modifying and Symptomatic Therapies

Multiple sclerosis is a chronic autoimmune demyelinating disorder of the central nervous system that typically presents between ages 20-40, with higher prevalence in women and Northern European/North American populations. Current therapeutic approaches include disease-modifying immunomodulatory agents (interferons, glatiramer acetate, monoclonal antibodies, fumarates, and others) and symptomatic treatments to manage disease progression and disability.

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Intrathecal IgM Species as Potential Prognostic Biomarkers in Relapsing-Remitting Multiple Sclerosis

This retrospective study examined whether specific IgM antibody markers in cerebrospinal fluid could predict disease progression in 37 relapsing-remitting MS patients over up to 17 years. Patients with both oligoclonal IgM bands and anti-S-nitrosylated protein IgM showed more aggressive disease, while those lacking both markers had more benign outcomes, suggesting these biomarkers may help guide clinical management decisions.

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Structure-Function Multilayer Network Integration and Cognition in Multiple Sclerosis

This study examined how integrated structural and functional brain networks in the frontoparietal region relate to cognitive performance in 780 people with relapsing-remitting MS. Higher multilayer network centrality and single-layer network parameters showed weak associations with cognitive test performance, but findings were not reproducible across different brain atlases, limiting their practical significance.

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Effect of Brain Gym on Cognition, Manual Dexterity and Bimanual Coordination in Multiple Sclerosis Patients

This randomized controlled trial compared educational kinesiology (brain gym) combined with conventional physical therapy against conventional therapy alone in 36 MS patients with mild cognitive impairment. The study group receiving brain gym showed significant improvements in cognitive function and hand coordination measures assessed via RehaCom and Purdue Pegboard tests over 4 weeks of treatment.