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A cross-sectional study of 150 UPDF soldiers returning from deployment found 16% screened positive for PTSD and 21% for moderate substance use disorder. Combat readiness training was associated with reduced risk of both PTSD and alcohol abuse, with alcohol use mediating the relationship between combat readiness and PTSD symptoms.
This narrative review examines evidence for psilocybin- and LSD-assisted treatment in patients with both alcohol use disorder and major depressive disorder, noting promising sustained effects on drinking frequency and symptom reduction. The authors argue for integrated therapeutic approaches using psychedelics to simultaneously address the high-prevalence comorbidity, while discussing methodological considerations for future clinical trials.
A one-year prospective study of 37 adults with ADHD found that methylphenidate treatment significantly reduced symptoms of internet, shopping, food, and sex addictions, with the proportion of patients having at least one behavioral addiction diagnosis decreasing from 51.4% to 35.1%. Changes in cognitive impulsivity, sluggish cognitive tempo, and mood/anxiety symptoms correlated moderately with improvements in internet addiction scores.
This review examines why infantile spasms commonly occur in Down syndrome by analyzing animal models (Ts65Dn and TcMAC21 mice) to identify abnormalities in brain excitation and inhibition, particularly involving GABA receptor dysfunction. The research provides insights into potential therapeutic targets by clarifying the neurobiological mechanisms underlying seizure predisposition in Down syndrome.
The EGUIDE project evaluated how educational lectures on clinical practice guidelines influenced 782 psychiatrists' treatment practices across 176 Japanese hospitals, comparing guideline adherence in over 11,000 patients with schizophrenia or major depressive disorder. Psychiatrists who participated in guideline education showed higher rates of guideline-recommended treatments including appropriate antipsychotic monotherapy and reduced unnecessary psychotropic co-prescriptions.