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This study examined whether genetic variations in UGT enzymes (which metabolize the antiepileptic drug lamotrigine) affect seizure control in 47 pregnancies of women with epilepsy. While UGT genotype did not directly predict seizure outcomes, recent pre-pregnancy seizure history (within 6-12 months) was a significant predictor of seizure recurrence during pregnancy and postpartum.
A 32-year-old man with known epilepsy experienced simultaneous bilateral anterior shoulder dislocations immediately after a generalized tonic-clonic seizure, a rare occurrence since seizure-related dislocations are typically posterior. Closed reduction under sedation followed by immobilization and rehabilitation achieved excellent functional recovery at 1-year follow-up, with seizure control emphasized as key to preventing recurrence.
The International League Against Epilepsy released an updated seizure classification in 2025 with six main revisions to improve clinical clarity, including replacing 'onset' in seizure class names, substituting 'consciousness' for 'awareness' to encompass both awareness and responsiveness, and replacing 'motor' with 'observable' features. The update also emphasizes chronological seizure semiology patterns, recognizes epileptic negative myoclonus as a new seizure type, and expands the use of epileptic spasms as a descriptor across focal and unknown seizures.
This survey examines current clinical practices among Italian epileptologists regarding prophylactic anti-seizure medication use in brain tumor patients. The study provides insights into specialist approaches to seizure prevention in this high-risk population.
This prospective study compared 105 adults with epilepsy to 115 healthy controls, assessing separation anxiety disorder using standardized clinical interviews and validated questionnaires. The research examined relationships between separation anxiety symptoms, perceived overprotection, and quality of life outcomes in the epilepsy group, finding lower rates of employment, education, and independent living among those with epilepsy.