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StudiuDemențeÎncredere înaltă21.06.2026

Asymmetrical β-amyloid deposition patterns and cognitive decline in Alzheimer's disease: findings from the SILCODE study

This longitudinal study examined asymmetric distribution of β-amyloid plaques across the brain in 148 participants spanning normal cognition to Alzheimer's disease dementia. The research found that β-amyloid lateralization varies by disease stage and correlates with cognitive performance, suggesting potential utility as a neuroimaging biomarker for tracking disease progression.

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Hypertension and Cognitive Disorders: A Review of Associations and Therapeutic Implications

This review examines how hypertension contributes to major neurocognitive disorders including Alzheimer's disease, vascular dementia, and Lewy body dementia through vascular damage, inflammation, and blood-brain barrier disruption. While antihypertensive medications show promise in some studies, evidence remains inconsistent, highlighting the need for long-term prospective research to clarify treatment effectiveness and the bidirectional relationship between hypertension and cognitive decline.

StudiuDemențeÎncredere înaltă21.06.2026

Brain Metabolic Resilience in Alzheimer's Disease: A Predictor of Cognitive Decline and Conversion to Dementia

This study quantified metabolic resilience using FDG-PET imaging in 848 participants from the ADNI database to assess its role in predicting cognitive decline and dementia conversion. Results showed that preserved brain glucose metabolism independently predicted slower cognitive decline and reduced dementia conversion risk, suggesting it is a valuable biomarker complementary to structural brain measures.

StudiuDemențeÎncredere înaltă21.06.2026

Dementia: Definition, Epidemiology, Prevention, Diagnosis, and Treatment

Dementia (major neurocognitive disorder) involves decline in one or more cognitive domains causing functional impairment, with Alzheimer disease being the most common type affecting approximately 6.9 million U.S. adults aged 65+. The article reviews current evidence on cognitive decline prevention, screening, diagnosis, treatment options, and quality of life considerations for both patients and caregivers.