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This study demonstrates that repetitive traumatic brain injury can trigger reactivation of herpes simplex virus-1 (HSV-1) in human brain tissue, leading to pathological features characteristic of Alzheimer's disease. The research was conducted using advanced 3D brain tissue models, providing insights into potential mechanisms linking TBI to neurodegenerative disease risk.
A survey of 207 U.S. Major League Rugby players examined their understanding of head injury assessment and return-to-play protocols, finding that understanding was not correlated with prior concussion history but was associated with international playing experience and trust in league protocols. The study identified gaps in player education and staffing as key factors affecting protocol comprehension and player safety.
This observational study of 110 traumatically injured individuals found that while fatigue and sleep disturbance were elevated compared to controls, these symptoms were not specifically attributable to mild traumatic brain injury itself. Rather, psychological distress and pain—common to all trauma survivors—were the primary predictors of fatigue and sleep disruption, regardless of head injury status.
This systematic review evaluated the effectiveness of psychological interventions for prolonged post-concussion symptoms lasting more than 12 months after mild traumatic brain injury. Cognitive Behavioural Therapy showed the strongest evidence for improving anxiety, anger, and mental well-being, though the overall evidence base remains preliminary and requires more rigorous research.
This study evaluated the feasibility and utility of ImPACT-QT, a brief iPad-based cognitive screening tool, in acutely hospitalized trauma patients with mild TBI. The test was completed in ~9 minutes with high usability, and memory scores significantly differentiated mTBI patients from non-TBI controls, suggesting potential clinical utility for rapid bedside cognitive assessment.