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StudiuTraumatisme cranio-cerebraleÎncredere înaltă29.06.2026

Rationale for Development of a Traumatic Brain Injury Case Definition for the National Concussion Surveillance System

The CDC developed a tiered case definition for self-reported traumatic brain injury (TBI) to improve national surveillance, addressing limitations of hospital-based data that undercount TBIs occurring in outpatient and untreated settings. This surveillance system aims to better estimate the public health burden of concussion and TBI across all causes of brain injury in the United States.

StudiuScleroză multiplăÎncredere înaltă29.06.2026

Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing

This study investigates circulating proteins and microRNAs in cerebrospinal fluid and serum as potential biomarkers to differentiate MS disease subtypes and guide treatment decisions. Analysis of two cohorts identified 13 cerebrospinal fluid proteins and 10 serum proteins that differed between MS patients and controls, with 16 serum microRNAs distinguishing between relapsing-remitting and secondary progressive MS.

StudiuScleroză multiplăÎncredere înaltă29.06.2026

Frailty in Multiple Sclerosis: A Scoping Review of Prevalence, Clinical Associations, and Outcomes

This systematic scoping review identified 11 studies examining frailty in people with multiple sclerosis, finding frailty prevalence ranges from 17–66% with early onset compared to the general population. Higher disability levels, longer disease duration, and progressive MS subtypes were consistently associated with frailty, which also correlated with reduced walking performance, poor sleep quality, fatigue, and lower quality of life.

StudiuEpilepsieÎncredere înaltă29.06.2026

The functional and molecular roles of p75 neurotrophin receptor in epilepsy

This review examines how p75 neurotrophin receptor (p75NTR) contributes to epilepsy development through altered neurotransmitter balance and increased pro-BDNF/p75NTR expression in brain cells. The authors synthesize current evidence on the mechanistic pathways linking p75NTR overexpression to epileptogenesis and seizure pathogenesis.

StudiuEpilepsieÎncredere bună29.06.2026

Epilepsy-Induced Altered Consciousness and Criminal Responsibility: Legal and Clinical Assessment Framework

This case analysis examines a driver with longstanding epilepsy who caused a traffic accident during a seizure-induced state of profound consciousness disturbance, addressing how courts determine criminal responsibility in such situations. The authors argue for expanded legal frameworks requiring multidisciplinary medical evaluation and therapeutic rather than purely penal measures to prevent future incidents and minimize psychiatric complications.

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