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StudiuAutismÎncredere înaltă22.06.2026

Male-Biased Social Deficits in Chd8+/R2219* Mouse Model of Autism Linked to Hippocampal Abnormalities

This preclinical study generated a CRISPR-Cas9 mouse model carrying a CHD8 mutation associated with autism risk and found that male mice exhibited greater social deficits mirroring human sex bias, alongside macrocephaly and whole-brain enlargement. MRI and functional connectivity analyses revealed that hippocampal expansion and disrupted hippocampal network connectivity specifically correlated with social deficit severity in males, establishing hippocampal pathology as a key neural substrate for sex-biased autism phenotypes.

StudiuAutismÎncredere bună22.06.2026

Emotion- and Region-Specific Gaze Differences in Parents of Children With Autism Spectrum Disorder

A study using eyetracking compared visual attention patterns in parents of children with ASD versus parents of typically developing children while viewing emotional faces. Parents of children with ASD showed selective increased attention to the mouth region specifically when viewing threat-related emotions (anger, fear), suggesting emotion- and region-specific gaze allocation differences rather than generalized attentional changes.

StudiuAutismÎncredere bună22.06.2026

Cocoa polyphenols mitigate valproic acid-induced autism-like phenotypes in zebrafish via metabolic and proteomic mechanisms: a pilot study

This pilot study examined whether cocoa extract containing polyphenols could reverse autism-like behavioral and gastrointestinal abnormalities induced by valproic acid exposure in zebrafish. Cocoa co-treatment ameliorated hyperactivity and gut dysfunction while normalizing key metabolic and protein markers of cellular stress.

StudiuAutismÎncredere înaltă22.06.2026

Differentiation between Autism Spectrum Disorder and Personality Disorders: A Systematic Review

This systematic review synthesizes clinical criteria distinguishing Autism Spectrum Disorder (ASD) from Personality Disorders in adults, addressing diagnostic challenges due to overlapping characteristics. The analysis of 684 individuals across multiple databases (2020-2024) reveals significant overlap particularly between ASD and Borderline Personality Disorder, with ASD characterized by cognitive rigidity and social interpretation difficulties versus personality disorders showing emotional dysregulation patterns.

StudiuAutism + ADHDÎncredere bună21.06.2026

Relationship between depression and sex steroid hormones in women with epilepsy

This study investigated associations between sex steroid hormones, antiseizure medications, and depression in 112 women with epilepsy compared to 50 healthy controls, finding a 18.8% depression prevalence and significant hormonal differences including elevated testosterone and altered FSH, estradiol, progesterone, and prolactin levels. Sex steroid hormones emerge as potential biomarkers for depression risk in women with epilepsy, with implications for treatment and prognosis.