Differentiation between Autism Spectrum Disorder and Personality Disorders: A Systematic Review

This systematic review synthesizes clinical criteria distinguishing Autism Spectrum Disorder (ASD) from Personality Disorders in adults, addressing diagnostic challenges due to overlapping characteristics. The analysis of 684 individuals across multiple databases (2020-2024) reveals significant overlap particularly between ASD and Borderline Personality Disorder, with ASD characterized by cognitive rigidity and social interpretation difficulties versus personality disorders showing emotional dysregulation patterns.