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Down syndrome patients show significantly elevated prevalence of autoimmune thyroid diseases (Hashimoto's thyroiditis and Graves' disease) compared to age-matched controls without the chromosomal abnormality. These conditions manifest at earlier ages in Down syndrome populations and do not correlate with gender or family history of autoimmune disease.
This research examines the role of mitochondrial dysfunction as a biological mechanism contributing to Alzheimer's disease development in individuals with Down syndrome. The study explores cellular energy production impairment and related pathological processes underlying early-onset dementia in this population.
A survey of 532 parents/caregivers of people with Down syndrome explored attitudes toward potential therapeutic interventions to improve neurocognition and phenotype. Responses revealed tensions between desires to enhance quality of life and concerns about erasing identity and personality, with some rejecting interventions as ableist and promoting the erasure of neurodiversity.
This specialist research examines biomarkers associated with amyloid protein pathology in individuals with Down syndrome, who have elevated risk for early-onset Alzheimer's disease. Understanding these molecular markers may help identify progression and guide early interventions in this population.
This study examines differences in attitudes toward research participation between decision-makers for individuals with Down syndrome and those without the condition. The research explores barriers and facilitators to research engagement in Down syndrome populations versus general populations.