Association between childhood trauma and 26-week treatment response in adolescents with major depressive disorder: a cohort study
This prospective cohort study of 150 adolescents with major depressive disorder found high prevalence of childhood trauma (emotional abuse 52%, emotional neglect 61.3%), with emotional abuse and neglect significantly associated with poorer treatment response at 26-week follow-up. The findings suggest childhood trauma adversely impacts antidepressant treatment efficacy in adolescents and highlight the need for trauma-informed care in depression management.
