NeuroPsy InfoHub adună studii și articole verificate editorial despre sănătate mintală și afecțiuni neurologice — pentru pacienți, familii și specialiști.
A cross-sectional study of 268 pregnant women examined the prevalence of Down syndrome screening using dual and quadruple serum marker tests during weeks 11-22 of gestation. Among 200 screened women (74.63%), 84% showed low-risk results and 16% showed high-risk results, with findings comparable to similar institutional studies.
This editorial addresses endocrine complications commonly associated with Down syndrome, including thyroid dysfunction, metabolic issues, and growth abnormalities. The piece discusses clinical manifestations and management considerations for healthcare providers treating individuals with Down syndrome across the lifespan.
Individuals with Down syndrome experience dysregulation of both innate and adaptive immune systems, resulting in increased susceptibility to autoimmunity and severe infections compared to the general population. Documented immune alterations include elevated cytokine levels, increased interferon signaling, shifts toward memory T-cell phenotypes, and reduced B-cell compartment size, which contribute to both autoinflammatory conditions and heightened infection severity.
This study compared interhemispheric communication efficiency between 11 individuals with Down syndrome and 13 controls using a fingertip cross-localization test. Results showed significantly reduced interhemispheric transfer efficiency in the Down syndrome group, suggesting potential corpus callosum dysfunction that may contribute to cognitive development differences.
This scoping review systematically analyzed existing research on bone growth, development, maintenance, and repair in individuals with Trisomy 21 (Down syndrome), identifying 16 relevant articles. Animal model studies revealed differences in bone development and reduced bone maintenance/repair, with evidence of osteoporotic bone phenotype in both male and female mice, highlighting the need for further understanding of bone health complications in this population.