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This study uses MRI to investigate structural brain changes associated with major depressive disorder, examining cortical thinning patterns across brain regions. The research contributes to understanding the neurobiological mechanisms underlying depression, moving beyond symptom description toward identifying neural signatures of the condition.
Research presented at the European Academy of Neurology Congress 2026 demonstrates that MS substantially affects non-physical aspects of life, with over half of patients reporting impacts on social functioning and nearly half reporting work-related consequences. The study highlights the importance of addressing psychosocial dimensions alongside physical symptoms in MS management.
This article critically examines divergent diagnostic criteria for mild traumatic brain injury (mTBI) used across clinical and forensic settings, including ACRM, VA/DoD, DSM-5-TR, ICD-11, and CISG frameworks, highlighting their differing evidentiary standards and practical limitations. The authors review evidence-based approaches to diagnostic uncertainty, emerging blood biomarkers (GFAP, UCH-L1, NfL, S100B), and the scope of neuropsychological opinion in legal contexts, addressing challenges in retrospective determination and mechanistic complexity in injury mechanisms.
This cross-sectional study of 222 RRMS patients examined how perfectionism and intolerance of uncertainty contribute to fear of relapse using validated psychological scales. Results showed perfectionism significantly predicts fear of relapse both directly and indirectly through intolerance of uncertainty, which mediates approximately 48% of this relationship.
This meta-analysis of 25 observational studies (24,596 pregnancies) found that pregnant women with epilepsy who experience seizures have increased risks of caesarean delivery, peripartum depression, preterm birth, and small-for-gestational-age infants compared to those without seizures. The review also examined how socioeconomic factors may influence seizure control during pregnancy.
