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This study protocol examines gut microbiota composition differences between Malaysian patients with major depressive disorder (in monotherapy and polypharmacy groups) and healthy controls using 16S rRNA gene sequencing. The research aims to fill knowledge gaps about how microbial metabolites influence mood and behavior in the Malaysian population.
This scoping review analyzed literature on routines and habits in ADHD across both children and adults, identifying four main affected domains: sleep hygiene, feeding, physical activity, and sedentary behaviors. The review found significant research gaps, including the absence of validated assessment tools specifically designed for ADHD routines/habits and limited intervention studies, with most research focusing on pediatric rather than adult populations.
This study proposes using YOLOv8-11 object detection models on preprocessed structural MRI scans to detect neuroanatomical abnormalities associated with autism spectrum disorder, achieving accuracy rates exceeding 98%. The framework processes 3D MRI data into 2D image sequences across multiple planes while accounting for age-related brain changes, demonstrating superior performance compared to traditional deep learning architectures for potential clinical support in early ASD diagnosis.
This systematic review examined 17 studies on cannabidiol (CBD), cannabidivarin (CBDV), and THC use in pediatric neurodevelopmental disorders, finding generally mild-to-moderate adverse effects with low treatment discontinuation rates. Preliminary evidence suggests behavioral improvements in autism and Fragile X syndrome, and seizure reduction in Rett syndrome, though most studies were observational or case series with differential effects between CBD alone and CBD combined with THC.
Researchers developed a flexible sensor system using liquid metal electrodes to detect color preferences in autistic children through touch-based interaction combined with machine learning. The system achieved 98% recognition accuracy and offers a non-burdensome method for individualized color preference assessment.