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StudiuEpilepsieÎncredere bună20.06.2026

Adverse events of dual anti-seizure medication: Real-life data from a tertiary epilepsy clinic

A retrospective study of 595 epilepsy patients on dual anti-seizure medications identified common adverse events including sleepiness (62%), concentration difficulties (55%), and memory problems (53%). Female sex, certain drug combinations (levetiracetam/valproic acid, lamotrigine/valproic acid), drug resistance, and focal/unclassified epilepsy were independently associated with higher adverse event burden.

StudiuEpilepsieÎncredere înaltă20.06.2026

Drug-Resistant Frontal Lobe Epilepsy: A Review of Epidemiology, Diagnosis, and Surgical Management

This review addresses the clinical challenge of drug-resistant frontal lobe epilepsy, the second most common epilepsy type, which is complicated by the frontal lobe's large size making seizure focus localization difficult. The article examines epidemiology, etiologic factors (particularly cortical developmental abnormalities), symptomatology, and advances in neurophysiological and neuroimaging techniques including magnetoencephalography, quantitative PET, 7T MRI, and artificial intelligence-assisted morphometric analysis to improve lesion detection and surgical outcomes.

StudiuEpilepsieÎncredere înaltă20.06.2026

The impact of the new definition of epilepsy on diagnosis, treatment, and short-term outcomes—A prospective study

A prospective study of 235 adult patients with first seizures examined how the 2014 ILAE definition of epilepsy (allowing earlier diagnosis) affected clinical outcomes compared to previous criteria. Among 146 patients diagnosed with epilepsy using new criteria, 72% remained seizure-free at 12-month follow-up, and anti-seizure medication significantly reduced seizure recurrence risk.

StudiuEpilepsieÎncredere bună20.06.2026

Pharmacogenetics of Anti-Seizure Medications in Arab Countries: A Comprehensive Review

This review examines how genetic variations in Arab populations influence the efficacy, safety, and individual responses to anti-seizure medications, identifying specific genetic markers that can predict drug resistance and optimize dosing. Genetic testing for variants in genes such as MTHFR, MDR1, ABCB1, and others enables personalized treatment approaches to improve seizure control and minimize adverse drug reactions.

StudiuEpilepsieÎncredere înaltă20.06.2026

Simultaneous Bilateral Anterior Shoulder Dislocation Following Epileptic Seizure: A Rare Case Report

A 32-year-old man with known epilepsy experienced simultaneous bilateral anterior shoulder dislocations immediately after a generalized tonic-clonic seizure, a rare occurrence since seizure-related dislocations are typically posterior. Closed reduction under sedation followed by immobilization and rehabilitation achieved excellent functional recovery at 1-year follow-up, with seizure control emphasized as key to preventing recurrence.