Adverse events of dual anti-seizure medication: Real-life data from a tertiary epilepsy clinic

A retrospective study of 595 epilepsy patients on dual anti-seizure medications identified common adverse events including sleepiness (62%), concentration difficulties (55%), and memory problems (53%). Female sex, certain drug combinations (levetiracetam/valproic acid, lamotrigine/valproic acid), drug resistance, and focal/unclassified epilepsy were independently associated with higher adverse event burden.