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StudiuAutismÎncredere bună28.06.2026

Brain-Targeted H₂S-Releasing Nanomicelle Shows Promise in Autism Spectrum Disorder Rat Models via Aerobic Glycolysis Enhancement

Researchers developed a mannose-modified nanomicelle (Man-LA) designed to deliver hydrogen sulfide directly to the brain via GLUT1 transporters in astrocytes, and demonstrated in rat autism models that it alleviates behavioral symptoms while promoting aerobic glycolysis and protecting hippocampal neurons. The study identifies dysregulation of astrocytic aerobic glycolysis and H₂S signaling as potentially important in autism pathophysiology, though these findings remain preclinical and require human validation.

StudiuAutism + ADHDÎncredere înaltă26.06.2026

Agomelatine versus escitalopram for depression in people with epilepsy: A randomized controlled trial

This double-blind randomized trial compared agomelatine and escitalopram in 51 people with epilepsy and major depressive disorder, evaluating effects on depression, seizure frequency, sleep, cognition, and quality of life. Both medications improved depression similarly with minimal adverse events; escitalopram showed greater quality-of-life improvement while agomelatine showed better verbal memory outcomes, with no significant effects on seizure frequency in either group.

StudiuAutism + ADHDÎncredere înaltă26.06.2026

Postoperative Serotonin Syndrome in a Patient with ADHD and Treatment-Resistant Depression

A case report describes a patient with ADHD and treatment-resistant depression who developed serotonin syndrome postoperatively due to concurrent use of venlafaxine, opioids, stimulants, and cannabis. The condition was diagnosed using Hunter criteria and successfully reversed through discontinuation of serotonergic medications and supportive care.

StudiuAutismÎncredere înaltă26.06.2026

Systematic Curation of Genetic Variants Associated with Autism Spectrum Disorder Using the EAGLE Framework

This study applied the Evaluation of Autism Gene Link Evidence (EAGLE) framework to systematically curate 222 genes associated with neurodevelopmental disorders, identifying 78 with definitive evidence for autism association, 43 with moderate evidence, and 99 with limited evidence. The analysis revealed differential expression and enrichment patterns at brain and cellular levels, establishing biological relevance for distinguishing autism-specific genetic associations from broader neurodevelopmental disorder phenotypes.

StudiuAutismÎncredere înaltă26.06.2026

EEG and Self-Report Reveal Intact Cognitive Appraisal but Reduced Affective-Sensorimotor Resonance for Others' Pain in Autism

This EEG study comparing adults with autism and neurotypical controls found that both groups could cognitively assess whether others experienced pain equally well. However, autistic adults showed reduced emotional and sensorimotor responses (measured via neural oscillations and self-report) when learning that a person could feel pain, suggesting differences in affective empathy rather than pain understanding.

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