The etiology of atypical bone health in individuals with Down syndrome
This scoping review systematically analyzed existing research on bone growth, development, maintenance, and repair in individuals with Trisomy 21 (Down syndrome), identifying 16 relevant articles. Animal model studies revealed differences in bone development and reduced bone maintenance/repair, with evidence of osteoporotic bone phenotype in both male and female mice, highlighting the need for further understanding of bone health complications in this population.