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A cross-sectional study of 268 pregnant women examined the prevalence of Down syndrome screening using dual and quadruple serum marker tests during weeks 11-22 of gestation. Among 200 screened women (74.63%), 84% showed low-risk results and 16% showed high-risk results, with findings comparable to similar institutional studies.
This editorial addresses endocrine complications commonly associated with Down syndrome, including thyroid dysfunction, metabolic issues, and growth abnormalities. The piece discusses clinical manifestations and management considerations for healthcare providers treating individuals with Down syndrome across the lifespan.
Individuals with Down syndrome experience dysregulation of both innate and adaptive immune systems, resulting in increased susceptibility to autoimmunity and severe infections compared to the general population. Documented immune alterations include elevated cytokine levels, increased interferon signaling, shifts toward memory T-cell phenotypes, and reduced B-cell compartment size, which contribute to both autoinflammatory conditions and heightened infection severity.
This study of 66 adults with Down syndrome found that lower gait performance scores on the Performance-Oriented Mobility Assessment independently predicted prodromal dementia and dementia risk. Higher BMI and gait dysfunction were both significant predictors of cognitive decline, suggesting mobility assessment may be useful in monitoring dementia progression in this population.
This study compared interhemispheric communication efficiency between 11 individuals with Down syndrome and 13 controls using a fingertip cross-localization test. Results showed significantly reduced interhemispheric transfer efficiency in the Down syndrome group, suggesting potential corpus callosum dysfunction that may contribute to cognitive development differences.