Informație de încredere. Sprijin real.

Ai întrebări despre autism, ADHD, anxietate sau depresie? Găsești ghiduri clare, verificate de specialiști. Acum, acces gratuit.

Spațiu publicitar disponibil — bannerul mare de susSpațiu publicitar disponibil — bannerul mare de sus

Explorează temele

Caută tot →

Sănătate mintală și neurodezvoltare

Afecțiuni neurologice

Articole și ghiduri recomandate

StudiuSindrom DownÎncredere înaltă20.06.2026

Aberrant tissue mechanics and mechanotransduction during heart development in Down syndrome

This study investigates how altered extracellular matrix composition and increased tissue stiffness in Down syndrome contribute to congenital heart defects, particularly septal defects which occur in 70% of individuals with the condition. Using mouse models and iPSC-derived cardiomyocytes with trisomy 21, researchers found that increased collagen and hyaluronic acid stiffness impairs cardiomyocyte proliferation and sarcomere organization, disrupting normal heart development through mechanotransduction pathways.

StudiuSindrom DownÎncredere înaltă20.06.2026

Detection of Down Syndrome-Associated Arthritis: Development and Feasibility of a Musculoskeletal Screening Tool

This multicenter study developed and piloted a Down syndrome-specific musculoskeletal screening tool to identify inflammatory arthritis (DA) in individuals with DS, finding a 2% confirmed diagnosis rate among positive screens. The tool is simple and feasible for clinical use, with symptoms of joint swelling, redness, warmth, and stiffness being most predictive of DA.

StudiuSindrom DownÎncredere bună20.06.2026

Outcomes of Strabismus Surgery in Patients with Down Syndrome

This retrospective study evaluated surgical outcomes for strabismus correction in 37 Down syndrome patients across esotropia, fourth nerve palsy, and mixed strabismus groups. Overall surgical success rates ranged from 40-86% depending on strabismus type, with 73% of cases achieving correction with a single procedure.

StudiuSindrom DownÎncredere înaltă20.06.2026

Fine Motor Development Growth Curves for Children with Down Syndrome

This study develops Down syndrome-specific percentile curves for fine motor and visual motor integration skills in children aged birth to 6 years using the PDMS-2 assessment. While fine motor development is delayed compared to typical development, the curves enable clinicians to identify children requiring intervention and help parents understand their child's developmental trajectory.

StudiuSindrom DownÎncredere înaltă20.06.2026

Development and Validation of a Health Measure for Down Syndrome

Researchers developed and validated a 25-item caregiver-reported health measure for individuals with Down syndrome aged 0-21 years, consisting of 3 domains and 7 scales with strong psychometric properties (Cronbach's α: 0.77-0.96, ICC: 0.71-0.94). The measure demonstrated construct validity, test-retest reliability, and ability to differentiate between Down syndrome and autism spectrum disorder in a national sample of 542 caregivers.