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StudiuSindrom DownÎncredere bună22.06.2026

Hyperphagia and Down Syndrome: A Case Report of Excessive Appetite and Behavioral Management

A 14-year-old boy with Down syndrome developed severe hyperphagia between ages 10-12, with BMI increasing significantly despite adequate nutrition, accompanied by compulsive eating patterns and food-related behavioral aggression. Treatment involved evidence-based behavioral interventions including token economy systems, structured meal scheduling, coping skills training, and communication supports to address eating behaviors.

StudiuSindrom DownÎncredere înaltă22.06.2026

Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome

This study of 66 adults with Down syndrome found that lower gait performance scores on the Performance-Oriented Mobility Assessment independently predicted prodromal dementia and dementia risk. Higher BMI and gait dysfunction were both significant predictors of cognitive decline, suggesting mobility assessment may be useful in monitoring dementia progression in this population.

StudiuSindrom DownÎncredere bună22.06.2026

Cytomegalovirus Pneumonia in Down Syndrome: A Case Report

A 50-year-old female with Down syndrome developed severe bilateral pneumonia caused by cytomegalovirus (CMV), requiring intensive care and mechanical ventilation, which resolved after ganciclovir treatment. This case highlights that CMV-induced pneumonia, rarely reported in Down syndrome patients, can be a life-threatening condition requiring early recognition and prompt antiviral intervention.

StudiuSindrom DownÎncredere bună22.06.2026

Interhemispheric Communication Efficiency in Down Syndrome: Evidence of Corpus Callosum Dysfunction

This study compared interhemispheric communication efficiency between 11 individuals with Down syndrome and 13 controls using a fingertip cross-localization test. Results showed significantly reduced interhemispheric transfer efficiency in the Down syndrome group, suggesting potential corpus callosum dysfunction that may contribute to cognitive development differences.

StudiuSindrom DownÎncredere înaltă22.06.2026

The etiology of atypical bone health in individuals with Down syndrome

This scoping review systematically analyzed existing research on bone growth, development, maintenance, and repair in individuals with Trisomy 21 (Down syndrome), identifying 16 relevant articles. Animal model studies revealed differences in bone development and reduced bone maintenance/repair, with evidence of osteoporotic bone phenotype in both male and female mice, highlighting the need for further understanding of bone health complications in this population.