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StudiuParkinsonÎncredere bună27.06.2026

Multi-session neurofeedback with implanted deep brain stimulation electrodes in Parkinson's disease patients

This exploratory study investigated the feasibility of repeated neurofeedback sessions using implanted DBS systems in 8 Parkinson's disease patients, where real-time visual feedback of beta oscillations from the subthalamic nucleus allowed patients to attempt regulation of neural activity across three separate days. Results showed significant beta power reduction in sessions 1 and 3, with dopaminergic medication negatively impacting downregulation performance while DBS stimulation enhanced it.

StudiuParkinsonÎncredere bună27.06.2026

Volume Alterations in Thalamic Subnuclei in Parkinson's Disease Dementia and Machine Learning-Based Prediction of Diagnosis and Severity

This study examines structural changes in specific thalamic regions among patients with Parkinson's disease dementia using advanced neuroimaging analysis. Machine learning algorithms are applied to these volumetric measurements to develop predictive models for diagnosis and disease severity assessment.

StudiuParkinsonÎncredere înaltă27.06.2026

Glucagon-like peptide-1 receptor agonists in movement disorders: Mechanisms, evidence, and future directions

GLP-1 receptor agonists, originally developed for diabetes and obesity, show neuroprotective properties in preclinical models of movement disorders by modulating neuroinflammation, oxidative stress, and protein aggregation. Clinical evidence is most advanced in Parkinson's disease, though early promise from exenatide and lixisenatide trials was not confirmed in larger phase III studies, with preliminary signals emerging in other movement disorders.

StudiuParkinsonÎncredere înaltă23.06.2026

Brain Cholinergic Imaging in Isolated REM Sleep Behavior Disorder: Distinctions and Similarities with Parkinson's Disease

This PET neuroimaging study examined cholinergic terminal density in 16 patients with isolated REM sleep behavior disorder (iRBD, a prodromal stage of Parkinson's disease) compared to 12 Parkinson's patients and 18 controls. Both patient groups showed similar cortical cholinergic denervation (11-12% reduction) with distinct regional patterns, while iRBD showed associations between lower cholinergic uptake and impaired executive/visuospatial function.

StudiuParkinsonÎncredere înaltă23.06.2026

POLG-associated Parkinson's disease-ALS overlap: Novel variant and first use of continuous subcutaneous foslevodopa/foscarbidopa infusion

A 38-year-old patient with a rare POLG gene variant developed an unusual overlap syndrome combining young-onset Parkinson's disease with ALS-like features (Brait-Fahn-Schwartz disease). Continuous subcutaneous infusion of foslevodopa/foscarbidopa achieved significant motor improvement at twelve months, representing the first documented use of this device-based therapy in this genetic condition.

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