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Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome

This cross-sectional study investigates whether disruptions in 24-hour rest-activity rhythms are associated with cognitive impairment and Alzheimer disease status in adults with Down syndrome using wrist actigraphy and validated cognitive assessments. The research employs rigorous statistical methods and controls for confounding variables including age, sex, intellectual disability level, and sleep apnea severity.

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Practice Patterns and Barriers in Assessing and Treating Autism Spectrum Disorder in Children With Down Syndrome

This study surveyed clinicians across specialties to identify barriers in diagnosing autism spectrum disorder in individuals with Down syndrome, where dual diagnosis (DS+ASD) occurs in 16-18% of cases but is often delayed. Results show most clinicians recognize that ASD diagnosis significantly impacts management, but challenges include limited access to specialized diagnostic evaluations and communication/behavioral difficulties that complicate assessment.

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Prevalence of Epilepsy and Young-Onset Dementia in Adults with Intellectual Disability: Contrasting Down Syndrome and Autism Diagnoses

This large-scale cross-sectional study analyzed Centers for Medicare and Medicaid Services data from over 847,000 adults with intellectual disability (ages 30-64) and compared them to over 1 million general population controls to examine prevalence of epilepsy and young-onset Alzheimer's disease and related dementias. Results showed significantly higher prevalence of both conditions and their comorbidity in the ID population, with autism spectrum disorder associated with greatest epilepsy risk and Down syndrome with greatest dementia risk.

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Alterations of gut microbiota in Down syndrome and their association with Alzheimer's disease

This study examined fecal microbiota composition and plasma Alzheimer's biomarkers in 58 adults with Down syndrome compared to controls, finding that DS individuals show reduced abundance of beneficial Roseburia bacteria and altered microbial profiles resembling those in Alzheimer's patients. The findings suggest a potential link between microbiota changes and cognitive decline in Down syndrome, contributing to understanding of why people with DS have higher Alzheimer's risk.