Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome

This cross-sectional study investigates whether disruptions in 24-hour rest-activity rhythms are associated with cognitive impairment and Alzheimer disease status in adults with Down syndrome using wrist actigraphy and validated cognitive assessments. The research employs rigorous statistical methods and controls for confounding variables including age, sex, intellectual disability level, and sleep apnea severity.