Five-year cardiovascular and fall risk in Parkinson's disease patients with orthostatic hypotension: A nationwide cohort study
This large cohort study of 111,368 Parkinson's disease patients found that orthostatic hypotension independently increased the 5-year risk of falls by 35% and cumulative fall counts by 22%, but was not associated with major vascular events. Among patients with orthostatic hypotension, pharmacotherapy paradoxically correlated with higher fall risk, suggesting complex clinical trade-offs in managing this autonomic feature.