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This systematic review synthesizes research on how performing cognitive tasks simultaneously affects balance and walking abilities in people with Down syndrome. The study examines evidence-based findings on dual-task interference and its implications for motor control assessment and intervention in this population.
This study uses cerebellar organoids and neural cultures to show that trisomy 21 causes extracellular matrix alterations that impair apical progenitor cell organization and reduce RAB11+ endosomes, leading to disrupted neural stem cell integrity. Supplementing cultures with extracellular matrix partially rescues these defects, demonstrating a functional role for ECM in maintaining proper apical organization during Down syndrome brain development.
Children with Down syndrome may have altered immune responses to routine vaccinations despite complete immunization records, resulting in inadequate protection against infections. This case describes a 5-year-old with Down syndrome who experienced recurrent respiratory infections despite adherence to standard vaccination schedules; additional pneumococcal vaccination led to notable clinical improvement, suggesting the value of immunology consultation and individualized vaccine response monitoring in this population.
Researchers established an integration-free iPSC line (KSCBi024-A) from blood cells of a 13-year-old boy with Down syndrome using episomal reprogramming vectors. The cells express pluripotency markers and can differentiate into multiple cell types, providing a valuable resource for studying trisomy 21 cellular mechanisms.
This large German study of 46,362 individuals with Down syndrome found lower overall cancer prevalence compared to matched controls, but significantly elevated risks for hematologic malignancies and testicular cancer, while breast, digestive, and skin cancers were less frequent. Notably, individuals with Down syndrome participated in cancer screening programs at substantially lower rates, highlighting a gap in preventive care access and adherence.