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This cross-sectional study of 222 RRMS patients examined how perfectionism and intolerance of uncertainty contribute to fear of relapse using validated psychological scales. Results showed perfectionism significantly predicts fear of relapse both directly and indirectly through intolerance of uncertainty, which mediates approximately 48% of this relationship.
This retrospective study evaluated lacosamide (LCM) monotherapy in 55 adult epilepsy patients, comparing those with (n=19) and without (n=36) psychiatric comorbidities over 6 months. Both groups achieved >80% seizure freedom with minimal psychiatric adverse effects (one case of irritability), and two patients with anxiety experienced symptom improvement, suggesting LCM is well-tolerated in epilepsy patients with pre-existing psychiatric conditions.
This study analyzed nearly 35,000 male veterans with spinal cord injury to establish age-adjusted PSA reference ranges for prostate cancer screening, accounting for factors like chronic urinary tract inflammation and hypogonadism that affect PSA levels in this population. The findings provide clinically relevant PSA threshold values specific to SCI patients, which differ from standard reference ranges used in the general population.
This systematic review synthesizes evidence from four studies to estimate the prevalence of familial hypercholesterolemia (FH) in stroke and TIA patients, finding a pooled prevalence of 0.96% overall and 2.89% in large artery atherosclerosis strokes. The authors acknowledge significant heterogeneity between studies and conclude that while evidence suggests FH may be relevant to cerebrovascular disease beyond cardiology, more research is needed for firm quantitative conclusions.
This research investigates theta burst stimulation, a neuromodulation technique, as a potential treatment for gambling disorder by measuring changes in craving intensity and relevant biological markers. The study examines whether this brain stimulation approach can reduce gambling cravings and identify associated neurobiological changes in affected patients.
