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StudiuTraumatisme cranio-cerebraleÎncredere înaltă28.06.2026

Neuropsychological Assessment in Mild Traumatic Brain Injury: Diagnostic Frameworks and Methodological Considerations

This article critically examines divergent diagnostic criteria for mild traumatic brain injury (mTBI) used across clinical and forensic settings, including ACRM, VA/DoD, DSM-5-TR, ICD-11, and CISG frameworks, highlighting their differing evidentiary standards and practical limitations. The authors review evidence-based approaches to diagnostic uncertainty, emerging blood biomarkers (GFAP, UCH-L1, NfL, S100B), and the scope of neuropsychological opinion in legal contexts, addressing challenges in retrospective determination and mechanistic complexity in injury mechanisms.

StudiuScleroză multiplăÎncredere înaltă28.06.2026

Fear of Relapse in Multiple Sclerosis: The Roles of Perfectionism and Intolerance of Uncertainty

This cross-sectional study of 222 RRMS patients examined how perfectionism and intolerance of uncertainty contribute to fear of relapse using validated psychological scales. Results showed perfectionism significantly predicts fear of relapse both directly and indirectly through intolerance of uncertainty, which mediates approximately 48% of this relationship.

StudiuEpilepsieÎncredere bună28.06.2026

Lacosamide monotherapy for epilepsy patients with comorbid psychiatric disorders: A retrospective chart review

This retrospective study evaluated lacosamide (LCM) monotherapy in 55 adult epilepsy patients, comparing those with (n=19) and without (n=36) psychiatric comorbidities over 6 months. Both groups achieved >80% seizure freedom with minimal psychiatric adverse effects (one case of irritability), and two patients with anxiety experienced symptom improvement, suggesting LCM is well-tolerated in epilepsy patients with pre-existing psychiatric conditions.

StudiuLeziuni medulareÎncredere înaltă28.06.2026

Defining Abnormal Prostate-Specific Antigen Values for Prostate Cancer Screening in Spinal Cord Injury Patients

This study analyzed nearly 35,000 male veterans with spinal cord injury to establish age-adjusted PSA reference ranges for prostate cancer screening, accounting for factors like chronic urinary tract inflammation and hypogonadism that affect PSA levels in this population. The findings provide clinically relevant PSA threshold values specific to SCI patients, which differ from standard reference ranges used in the general population.

StudiuAVC și AITÎncredere bună28.06.2026

Prevalence of Familial Hypercholesterolemia in Stroke and Transient Ischemic Attack Populations: A Systematic Review and Meta-Analysis

This systematic review synthesizes evidence from four studies to estimate the prevalence of familial hypercholesterolemia (FH) in stroke and TIA patients, finding a pooled prevalence of 0.96% overall and 2.89% in large artery atherosclerosis strokes. The authors acknowledge significant heterogeneity between studies and conclude that while evidence suggests FH may be relevant to cerebrovascular disease beyond cardiology, more research is needed for firm quantitative conclusions.

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