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Autism

Spectrul autist și particularitățile asociate.

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StudiuAutismÎncredere bună22.06.2026

Autism Spectrum Disorder and Cardiovascular Risk: Frontal QRS-T Angle and Systemic Immune-Inflammation Markers in Youth

This case-control study examined 84 children/adolescents with autism and 82 healthy controls, finding that youth with autism had higher resting heart rates, wider frontal QRS-T angles on ECG, and modestly elevated systemic immune-inflammation indices compared to controls. Autism severity scores correlated with both inflammatory markers and ECG findings, suggesting a link between systemic inflammation and cardiac autonomic dysregulation in autism spectrum disorder.

StudiuAutismÎncredere bună22.06.2026

Neural Processing of Emotional Words in Youth with Autism Spectrum Disorder: An Event-Related Potential Study

This ERP study compared 20 youth with autism spectrum disorder (ages 8.5–17.7 years) to 20 typically developing peers during emotional word processing tasks. Results showed intact early-stage neural responses but significantly reduced late positive component activity in autistic youth during emotional word categorization, suggesting differences in top-down evaluative processing of emotions.

StudiuAutismÎncredere înaltă22.06.2026

The Therapeutic Engagement Index in Autism: A Research Framework for Understanding Intervention Responsiveness

This paper introduces the Therapeutic Engagement Index (TEI), a multidimensional framework for understanding why autistic children respond differently to comparable interventions by examining observable factors affecting therapeutic accessibility and engagement. TEI is proposed as a research construct—not a validated diagnostic tool or compliance measure—to identify modifiable conditions that enhance how children can access, tolerate, and benefit from therapeutic input within specific intervention contexts.

StudiuAutismÎncredere bună22.06.2026

Emotion- and Region-Specific Gaze Differences in Parents of Children With Autism Spectrum Disorder

A study using eyetracking compared visual attention patterns in parents of children with ASD versus parents of typically developing children while viewing emotional faces. Parents of children with ASD showed selective increased attention to the mouth region specifically when viewing threat-related emotions (anger, fear), suggesting emotion- and region-specific gaze allocation differences rather than generalized attentional changes.

StudiuAutismÎncredere bună22.06.2026

Cocoa polyphenols mitigate valproic acid-induced autism-like phenotypes in zebrafish via metabolic and proteomic mechanisms: a pilot study

This pilot study examined whether cocoa extract containing polyphenols could reverse autism-like behavioral and gastrointestinal abnormalities induced by valproic acid exposure in zebrafish. Cocoa co-treatment ameliorated hyperactivity and gut dysfunction while normalizing key metabolic and protein markers of cellular stress.

StudiuAutism + ADHDÎncredere înaltă22.06.2026

Vaccine Hesitancy and Refusal in Parents of Children with Autism Spectrum Disorder and Developmental Delays: A Cross-Sectional Study

This study examined vaccine refusal rates among 154 parents of children with ASD or other developmental delays, finding that reported vaccine refusal increased from 3.9% before diagnosis to 9.7% after diagnosis, primarily driven by the false belief that vaccines caused their child's condition. The research documents the real public health harm from vaccine-autism misinformation while providing no scientific support for any vaccine-autism connection.

StudiuAutism + ADHDÎncredere înaltă21.06.2026

Epidemiological Study of Traumatic Brain and Spinal Injuries in Pediatric Patients: One-Year Analysis of Prevalence, Causes and Trends in Bulgaria

This retrospective study analyzed medical records of pediatric patients (under 18 years) admitted to a Bulgarian hospital emergency department over one year to determine prevalence, causes, and trends of traumatic brain and spinal cord injuries. Among 38,504 emergency department visits, 32% were children, with 0.3% hospitalized for neurosurgical conditions including TBI and SCI.

StudiuAutism + ADHDÎncredere bună21.06.2026

Relationship between depression and sex steroid hormones in women with epilepsy

This study investigated associations between sex steroid hormones, antiseizure medications, and depression in 112 women with epilepsy compared to 50 healthy controls, finding a 18.8% depression prevalence and significant hormonal differences including elevated testosterone and altered FSH, estradiol, progesterone, and prolactin levels. Sex steroid hormones emerge as potential biomarkers for depression risk in women with epilepsy, with implications for treatment and prognosis.

StudiuAutism + ADHDÎncredere bună21.06.2026

Neuropsychiatric Disorders and Burn Trauma: Clinical Epidemiology from a Tertiary Hospital

A prospective observational study over 24 months analyzed burn injury characteristics in patients with underlying neuropsychiatric conditions, finding epilepsy as the most common disorder (66.52%) followed by intellectual disability and dementia. Female patients experienced higher rates of severe burns and scalding injuries with more frequent third-degree burns and head/neck involvement compared to males.

StudiuAutism + ADHDÎncredere bună21.06.2026

Psychiatric Comorbidities in Functional Neurological Disorders and Psychogenic Non-Epileptic Seizures: Systematic Review and Policy Recommendations

This systematic review examines psychiatric comorbidities associated with Functional Neurological Disorders (FND) and Psychogenic Non-Epileptic Seizures (PNES), finding these are not autonomous conditions but develop alongside autism, borderline personality disorder, PTSD, and alexithymia. The authors propose a biopsychosocial model where early trauma, abuse, and neglect contribute to progressive neurological sensitivity, particularly in young female patients, and recommend improved assessment and integrated treatment policies.

StudiuAutism + ADHDÎncredere bună21.06.2026

Anxiety and Depression after Spinal Cord Injury: A Cross-Sectional Study

This study examined the prevalence of depression and anxiety in individuals with subacute and chronic spinal cord injury using validated psychological assessment tools (BDI and STAI scales). Results showed significant alterations in both depression and anxiety levels, with differences noted between subacute and chronic phases; early psychological assessment and intervention are recommended to prevent cognitive and mental health complications.

StudiuAutism + ADHDÎncredere bună21.06.2026

Depression and ADHD as predictors of exercise addiction: A cross-sectional study in frequent exercisers

This cross-sectional study of 173 frequent exercisers (>10 hours/week) examined relationships between depression, ADHD symptoms, and exercise addiction using standardized scales and regression analyses. Depressive and ADHD symptoms were significantly positively correlated with exercise addiction symptoms, with depression emerging as the stronger predictor after controlling for age and gender.

StudiuAutism + ADHDÎncredere înaltă21.06.2026

Infantile Spasms in Pediatric Down Syndrome: Neurobiological Mechanisms and Therapeutic Approaches

This review examines why infantile spasms commonly occur in Down syndrome by analyzing animal models (Ts65Dn and TcMAC21 mice) to identify abnormalities in brain excitation and inhibition, particularly involving GABA receptor dysfunction. The research provides insights into potential therapeutic targets by clarifying the neurobiological mechanisms underlying seizure predisposition in Down syndrome.

StudiuAutism + ADHDÎncredere înaltă21.06.2026

Effect of Educational Interventions on Psychiatrists' Adherence to Treatment Guidelines for Schizophrenia and Depression: A Multicenter Implementation Study

The EGUIDE project evaluated how educational lectures on clinical practice guidelines influenced 782 psychiatrists' treatment practices across 176 Japanese hospitals, comparing guideline adherence in over 11,000 patients with schizophrenia or major depressive disorder. Psychiatrists who participated in guideline education showed higher rates of guideline-recommended treatments including appropriate antipsychotic monotherapy and reduced unnecessary psychotropic co-prescriptions.

StudiuAutismÎncredere înaltă21.06.2026

Association of Cognitive and Adaptive Skills with Internalizing and Externalizing Problems in Autistic Children and Adolescents

This study of 2,759 autistic children and adolescents examined how cognitive and adaptive skills relate to mental health and behavioral problems across varying levels of intellectual ability. Results showed adaptive skills (communication, daily living, socialization) were protective against both internalizing and externalizing problems, with differential associations depending on whether intellectual disability was present.

PresăAutismÎncredere înaltă20.06.2026

Autism Mutations Converge on Shared Early Brain Pathways

Research demonstrates that hundreds of genetically diverse causes of autism dysfunction converge on common molecular pathways during early brain development. This finding suggests potential shared therapeutic targets despite the genetic heterogeneity of autism spectrum disorder.

StudiuAutism + ADHDÎncredere înaltă20.06.2026

Mental Health Problems in Traumatic Spinal Cord Injury Patients: An Umbrella Systematic Review

This umbrella systematic review synthesized 20 systematic reviews to assess the prevalence and correlates of mental illness in traumatic spinal cord injury patients, finding depression (up to 43%), PTSD (up to 62%), anxiety (27%), and hazardous alcohol use (≥50%) as major concerns. Common risk factors included pain, injury severity, low social support, and maladaptive coping, though evidence for effective interventions was limited.