Autism Spectrum Disorder and Cardiovascular Risk: Frontal QRS-T Angle and Systemic Immune-Inflammation Markers in Youth

This case-control study examined 84 children/adolescents with autism and 82 healthy controls, finding that youth with autism had higher resting heart rates, wider frontal QRS-T angles on ECG, and modestly elevated systemic immune-inflammation indices compared to controls. Autism severity scores correlated with both inflammatory markers and ECG findings, suggesting a link between systemic inflammation and cardiac autonomic dysregulation in autism spectrum disorder.