Scleroza multiplă și viața cu aceasta.
71 de articoleA retrospective analysis of 41 MS patients with uveitis compared to 123 MS controls found that disability accumulation (time to reach EDSS 3) occurred faster in patients with concurrent uveitis. The findings suggest that uveitis may be associated with worse MS disease progression.
A descriptive study of 170 MS patients across Morocco found female predominance, relapsing-remitting MS as the most common type, and common symptoms including fatigue, cognitive issues, and spasticity. Disease-modifying therapies (interferon beta-1a, azathioprine) were used alongside traditional/complementary medicine (cupping, Quranic recitation, apitherapy), with professional activity, treatment satisfaction, and stress significantly associated with relapse frequency.
This review examines recent neuroimaging technologies including MRI, PET, ocular imaging, and machine learning supported by MS research initiatives to better detect early MS pathology and monitor treatment response. The authors emphasize that while these biomarkers show promise for predicting and monitoring disease progression and may serve as clinical trial endpoints, longitudinal studies are needed to translate these measures into routine clinical practice.
A 33-year-old woman with relapsing-remitting MS treated with fingolimod for 5 years developed a solitary skin lesion that proved to be cryptococcal infection on biopsy, likely due to severe lymphocyte suppression from the immunosuppressive therapy. The case highlights the importance of thorough investigation of persistent skin lesions in MS patients on fingolimod, as only 6 such cutaneous cryptococcal infections have been previously reported in the literature.
This Cochrane review evaluates the efficacy and safety of alemtuzumab, a humanized monoclonal antibody, for treating various forms of multiple sclerosis compared to placebo or other active treatments. Primary outcomes include relapse-free survival, sustained disease progression, and adverse events, with secondary measures encompassing disability progression, quality of life, and MRI-detected lesions.
This review examines how biological aging accelerates disease progression in multiple sclerosis, particularly in progressive forms resistant to current treatments. Evidence from animal models and clinical biomarkers (telomere length, DNA methylation) suggests MS patients experience accelerated aging, opening potential avenues for senotherapy-based interventions targeting aging-related pathways.
This study examined cardiovascular autonomic dysfunction in women with relapsing-remitting MS by measuring beat-to-beat blood pressure variability and sympathetic baroreflex sensitivity compared to healthy controls. The research hypothesized that reduced sympathetic control in MS patients leads to impaired blood pressure regulation, using continuous electrocardiogram and blood pressure monitoring along with muscle sympathetic nerve activity recordings.
This review examines autophagy—a cellular degradation process—as a double-edged sword in multiple sclerosis, showing both protective effects (reducing oxidative stress and inflammation) and harmful effects (promoting demyelination when over-activated). The paper discusses how autophagy modulates immune cell activation and oligodendrocyte function, suggesting selective autophagy modulation could be a therapeutic strategy depending on disease context.
This cross-sectional study used magnetic resonance fingerprinting (MRF) to measure T1 and T2 relaxation times in brain tissue of healthy controls, relapsing-remitting MS patients, and secondary progressive MS patients, finding progressive increases in relaxation times across disease stages. The findings suggest MRF may be useful for quantitative tissue characterization and differentiation between MS disease subtypes and disease progression.
This systematic review examines scientific evidence on neuropsychological interventions targeting cognitive impairment in people with relapsing-remitting MS, a common disabling neurological disease in young adults. Analysis of 15 articles meeting rigorous inclusion criteria found that most cognitive rehabilitation programs demonstrated effectiveness, though methodological standardization remains lacking in this field.
Research identifies a specific strain of Tyzzerella nexilis enriched in secondary progressive MS that carries numerous mobile genetic elements and lacks defence mechanisms against them. In germ-free mice, colonisation with this strain increases susceptibility to experimental autoimmune encephalomyelitis through TLR5 stimulation by flagella and production of neuroactive reduced sulphur compounds, suggesting horizontal gene transfer may drive MS progression via gut microbiome alterations.
This study compared executive function performance in 24 individuals with relapsing-remitting multiple sclerosis and 24 matched healthy controls using standardized cognitive tests. Results showed selective impairment in divided attention and working memory updating in MS patients under high cognitive demand, while attentional shifting and inhibition remained intact.
This cross-sectional study of 78 women (38 with relapsing-remitting MS and 40 healthy controls) examined the relationship between depressive symptoms and sedentary behavior in MS patients. The research found significant associations between depression and increased sedentary time in women with MS, suggesting depression is a key factor contributing to reduced physical activity in this population.
This research examines whether gut microbiota composition could serve as a biomarker for diagnosing or predicting the course of multiple sclerosis. The study explores the relationship between bacterial communities in the intestine and MS disease progression, a recognized area of MS pathophysiology research.
This study applies functional brain imaging techniques to identify neurobiological markers associated with fall risk in older adults with multiple sclerosis. The research aims to develop predictive models that could improve clinical assessment and prevention strategies for falls in this vulnerable population.
This study investigates structural brain differences in grey matter related to mobility function, comparing older adults with MS to those without the disease. The research uses neuroimaging to identify which brain regions correlate with physical mobility capacity in MS and healthy aging.
A multicenter prospective study measured serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels in 115 relapsing-remitting MS patients treated with ocrelizumab over one year to identify biomarkers predicting treatment response. Elevated baseline sNfL and sGFAP levels were associated with treatment failure due to ongoing inflammation, while most patients with progression without relapse showed low sNfL levels, suggesting these biomarkers may help predict which patients will achieve disease activity remission.
This prospective study compared serum pleiotrophin (PTN) levels in 168 MS patients across three disease subtypes (RRMS, PPMS, SPMS) against 41 healthy controls, finding significantly lower PTN levels in MS patients overall and in RRMS and SPMS subgroups. The findings suggest pleiotrophin may play a role in MS pathogenesis and could be investigated as a potential biomarker for certain disease phenotypes.