Serum Biomarkers of Response to Ocrelizumab in Relapsing-Remitting Multiple Sclerosis

A multicenter prospective study measured serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels in 115 relapsing-remitting MS patients treated with ocrelizumab over one year to identify biomarkers predicting treatment response. Elevated baseline sNfL and sGFAP levels were associated with treatment failure due to ongoing inflammation, while most patients with progression without relapse showed low sNfL levels, suggesting these biomarkers may help predict which patients will achieve disease activity remission.