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Epilepsie

Crize epileptice și managementul lor.

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StudiuEpilepsieÎncredere bună22.06.2026

Efficacy of Medium-Chain Triglyceride Enriched Diet Combined with Zonisamide in Dogs with Idiopathic Epilepsy: A Randomized Controlled Crossover Trial

A double-blinded, placebo-controlled crossover study evaluated MCT-enriched therapeutic diet combined with zonisamide in 7 dogs with idiopathic epilepsy over 6 months. While no significant difference in seizure frequency was found between diet groups overall, individual responses varied with 3 of 7 dogs achieving ≥50% seizure reduction during the MCT diet period, including one achieving seizure freedom.

StudiuEpilepsieÎncredere bună22.06.2026

Seizure-precipitating factors in Border Collies with idiopathic epilepsy: clinical case observations

This veterinary study examines seizure triggers in six Border Collies with idiopathic epilepsy, identifying breed-specific environmental and behavioral factors such as stress, lack of mental stimulation, social stressors, and external stimuli. Management strategies targeting identified triggers resulted in reduced seizure frequency or seizure freedom in these cases, demonstrating the clinical value of recognizing individualized precipitating factors in canine epilepsy.

StudiuEpilepsieÎncredere bună22.06.2026

Simultaneous Bilateral Femoral Neck Fractures in a Pediatric Patient Caused by Epileptic Convulsions: A Case Report

A 13-year-old boy with epilepsy sustained simultaneous bilateral femoral neck fractures during an epileptic seizure, marking the first reported case of this injury pattern in pediatric epilepsy literature. The fractures were successfully treated with closed reduction, internal fixation, and ultrasound therapy, with bone union confirmed at 6 months, highlighting the importance of screening for fractures in children with post-seizure complaints.

StudiuEpilepsieÎncredere înaltă22.06.2026

Anti-seizure medication response and glymphatic system function in focal epilepsy: a DTI-ALPS study

This study examined glymphatic system function in 100 focal epilepsy patients versus 79 healthy controls using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS). Poor responders to anti-seizure medication showed significantly lower DTI-ALPS indices compared to good responders, suggesting impaired glymphatic clearance may relate to medication resistance in focal epilepsy.

StudiuEpilepsieÎncredere bună22.06.2026

Dostoevsky's Epilepsy and its Portrayal in The Brothers Karamazov

Fyodor Dostoevsky, a 19th-century Russian novelist with epilepsy, incorporated his personal experience with seizure disorder into his novels, particularly in The Brothers Karamazov where he explores family dynamics and uses psychogenic non-epileptic seizures as a narrative element in the character Smerdyakov's criminal alibi.

StudiuEpilepsieÎncredere înaltă22.06.2026

Epilepsy Due to Solitary Calcified Cysticercus Granuloma

Calcified neurocysticercosis (NCC) is a major cause of acquired adult-onset epilepsy in low and middle-income countries, responsible for approximately 30% of seizure cases. Focal-onset seizures typically respond well to anti-seizure monotherapy, and these seizure disorders are largely preventable through appropriate management of NCC stages.

StudiuEpilepsieÎncredere înaltă22.06.2026

Complete Atrioventricular Block Mimicking Epileptic Seizure: Urinary Incontinence Without Convulsions

A 70-year-old man presented with recurrent episodes of brief unresponsiveness and urinary incontinence without convulsions, initially suspected as temporal lobe epilepsy based on EEG findings. Subsequent cardiac investigations revealed complete atrioventricular block requiring pacemaker implantation, highlighting the diagnostic challenge of distinguishing syncope from epileptic seizures and the importance of careful EEG interpretation.

StudiuEpilepsieÎncredere înaltă22.06.2026

Late-onset epilepsy with cognitive symptoms: Clinical and neuroimaging comparison with probable Alzheimer's disease

This study compares cognitive, neuropsychological, and neuroimaging profiles of 26 late-onset epilepsy (LOE) patients with cognitive symptoms to 26 probable Alzheimer's disease (AD) patients, using comprehensive assessments including ACE-III cognition testing and 18F-FDG PET-CT imaging. Results showed that while LOE patients exhibited significant cognitive impairment (18% with dementia-range deficits), they demonstrated different cognitive profiles than AD patients, with better naming, memory, and visuospatial abilities but comparable deficits in executive function and attention.

StudiuEpilepsieÎncredere bună21.06.2026

Prediction of Epileptic Seizure Using Deep Learning Techniques

This study proposes a deep learning approach for predicting epileptic seizures using EEG signal analysis, employing convolutional neural networks for feature extraction and Bi-LSTM for classification. The method achieved 99.61% accuracy and aims to improve patient quality of life through early seizure detection and timely intervention.

StudiuEpilepsieÎncredere înaltă21.06.2026

Systematic Literature Review of Humanistic and Economic Burden of Focal Epilepsy and Primary Generalized Tonic-Clonic Seizures in Adults

This systematic review analyzed 136 studies to assess the humanistic and economic impact of focal epilepsy and primary generalized tonic-clonic seizures in adults, examining patient outcomes, quality of life, productivity loss, and caregiver burden. Findings demonstrate that epilepsy, particularly focal epilepsy, imposes substantial burden including poor work productivity, increased sick days, early retirement, and significant caregiver costs, with greater impact associated with high seizure frequency and medication resistance.

StudiuEpilepsieÎncredere înaltă21.06.2026

Machine Learning Models for Predicting Anti-Seizure Medication Response in Epilepsy: A Systematic Review

This systematic review of 37 studies examines how machine learning models can predict individual patient responses to anti-seizure medications by analyzing clinical data, brain imaging, EEG, and genetic information. While some models show promising accuracy, results vary widely, and the field faces significant limitations related to data quality and quantity that require further research and standardization.

StudiuEpilepsieÎncredere bună21.06.2026

Switching from carbamazepine to lacosamide improves elevated gamma-glutamyl transpeptidase levels in focal epilepsy patients

A clinical study of 12 adult epilepsy patients with elevated liver enzyme (GGT) levels found that switching from carbamazepine to lacosamide resulted in significant reduction in GGT levels and normalization in most patients. The medication switch was conducted abruptly without gradual cross-titration and did not result in increased seizure incidence over one month of follow-up.

StudiuEpilepsieÎncredere înaltă21.06.2026

Case Report: Lacosamide Unmasking SCN5A-Associated Brugada Syndrome in a Young Female with Epilepsy

A 33-year-old woman with epilepsy experienced cardiac arrest during intravenous lacosamide treatment, revealing previously undiagnosed Brugada syndrome caused by an SCN5A gene mutation (c.2893C>T, p.Arg965Cys). The case demonstrates a rare but serious adverse interaction between the antiepileptic drug lacosamide and genetic cardiac ion channel susceptibility, highlighting the need for cardiac screening in patients with family history of sudden cardiac death before lacosamide initiation.

StudiuEpilepsieÎncredere bună21.06.2026

Relationship between Anaplastic Lymphoma Kinase Inhibitors and Seizure Disorders: A Post-Marketing Surveillance Study

This pharmacovigilance study analyzed FDA adverse event reports to investigate whether ALK inhibitors (crizotinib, ceritinib, alectinib, brigatinib, lorlatinib) are associated with seizures using Bayesian statistical methods. Results showed varying signal detection scores across different ALK inhibitors, with ceritinib, brigatinib, alectinib, and lorlatinib demonstrating stronger associations with seizure disorders compared to crizotinib.

StudiuEpilepsieÎncredere bună21.06.2026

Optimal EEG Duration for Detecting Epileptiform Abnormalities Across Patient Groups: A Retrospective Analysis

This retrospective study analyzed EEG recordings to determine optimal recording duration for detecting epileptiform abnormalities in patients with first seizure versus established epilepsy. Results showed detection rates of 37.6% and 57.4% respectively, with factors like anti-seizure medication use and seizure frequency significantly influencing detection, suggesting individualized EEG protocols based on clinical presentation.

StudiuEpilepsieÎncredere bună21.06.2026

Changes in Gut Flora in Patients with Epilepsy: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis examined alterations in gut microbiota composition in epilepsy patients compared to healthy controls across multiple databases. While alpha diversity did not differ significantly, specific bacterial taxa showed significant changes including increased Verrucomicrobia and Akkermansia but decreased Lactobacillus in epilepsy patients.

StudiuEpilepsieÎncredere bună21.06.2026

MSCNet-FS: An Intelligent Epileptic Seizure Anticipation Model Using Multi-Serial Cascaded Networks and EEG Scalogram Analysis

This study presents a machine learning model designed to anticipate epileptic seizures by analyzing EEG scalogram images through a multi-serial cascaded network with optimized feature selection. The approach uses the Archimedes Optimization algorithm for feature selection followed by Bi-directional LSTM processing to provide timely seizure detection.