Autentificare
NeuroPsy InfoHubÎnțelege · Sprijin · ProgresCere sprijin
← Toate temele

Demențe

Boala Alzheimer și alte forme de demență.

73 de articole
← Toate secțiunile

Studii și știri

PublicToțiPentru oricineSpecialiști
VârstăToate vârsteleCopiiTineriAdulțiVârstnici
PresăDemențeÎncredere bună23.06.2026

Psychological traits linked to molecular subtypes of Alzheimer's dementia in postmortem brain analysis

A study of 822 deceased older adults found that stable psychological characteristics, particularly neuroticism and loneliness, were associated with different molecular patterns of Alzheimer's disease pathology in brain tissue. Purpose in life showed inverse associations with certain Alzheimer's subtypes, suggesting psychological factors may influence the biological heterogeneity of the disease beyond standard neuropathological markers.

PresăDemențeÎncredere bună23.06.2026

Sleep Habits and AQP4 Gene Variants Interact to Influence Alzheimer's Risk

Research indicates that specific variants of the AQP4 gene interact with poor sleep patterns to accelerate grey matter loss and cognitive decline. This represents a gene-environment interaction where modifiable sleep behavior may influence the expression of genetic risk for Alzheimer's disease.

StudiuDemențeÎncredere bună23.06.2026

Type 2 diabetes mellitus moderates the relationship between interleukin-8 and Alzheimer's disease pathology in mild cognitive impairment

This study analyzed 373 mild cognitive impairment participants to investigate how type 2 diabetes modifies the association between baseline plasma IL-8 levels and cognitive decline, amyloid pathology, and neurodegeneration. Results showed that in the T2DM group, higher IL-8 was associated with slower clinical decline, lower hippocampal amyloid burden, and reduced brain atrophy, suggesting IL-8's role is context-dependent and may reflect an adaptive immune response under metabolic stress.

StudiuDemențeÎncredere bună23.06.2026

D-chiro-inositol Modulates Insulin Signaling and Reduces Amyloid Burden and Neuroinflammation in Preclinical Alzheimer's Disease Models

This preclinical study demonstrates that D-chiro-inositol, a natural compound with insulin-mimetic properties, reduces amyloid-beta production and promotes neuroprotection in cultured neurons and transgenic mouse models of Alzheimer's disease. The compound enhances insulin receptor signaling, modulates tau-related kinase activity, and shifts immune responses in the brain toward less inflammatory states, suggesting potential therapeutic mechanisms worth further investigation.

StudiuDemențeÎncredere înaltă23.06.2026

Unawareness of Deficits in Mild Cognitive Impairment: A Systematic Review of Its Role in Progression to Alzheimer's Disease

This systematic review examines whether reduced awareness of cognitive decline in individuals with mild cognitive impairment (MCI) serves as a predictor of conversion to Alzheimer's disease or dementia. The study synthesized evidence from 11 peer-reviewed longitudinal studies across major databases to clarify whether diminished insight into cognitive abilities in early stages could identify at-risk individuals who need timely intervention.

StudiuDemențeÎncredere bună23.06.2026

Sex Differences in Adverse Childhood Experiences and Brain Structure/Cognition Along the Alzheimer's Disease Continuum

This study investigates why women develop Alzheimer's disease at higher rates by examining how adverse childhood experiences (ACEs) affect brain structure and cognitive function differently in men versus women across stages of cognitive decline. Results show women reported more ACEs, and these experiences were associated with reduced brain volumes in cognitively unimpaired men and memory/executive function deficits in women with mild cognitive impairment, suggesting psychosocial factors may contribute to sex differences in dementia risk.

StudiuDemențeÎncredere înaltă23.06.2026

Digital Speech-Based Markers to Advance Prognosis in Alzheimer's Disease

Speech-based digital markers offer a scalable, non-invasive approach to predicting cognitive decline and complementing blood biomarkers in Alzheimer's disease, though large multilingual longitudinal datasets are lacking. The SpeechDx study is a 3-year multinational observational research program (n=2006) designed to develop and validate speech-based tools for early risk assessment and personalized intervention in preclinical populations.

StudiuDemențeÎncredere bună22.06.2026

Diagnosis of Alzheimer's Dementia and Vehicle Driving Restriction: A Scoping Review

This scoping review examined literature (2000-2022) on driving safety and restrictions for patients with Alzheimer's disease and cognitive decline, finding no sufficiently sensitive psychometric tests to reliably assess driving competence in older adults with cognitive deficits. The authors conclude there is insufficient robust evidence to recommend either continuation or cessation of driving for patients with mild cognitive impairment or mild dementia, while noting driving restrictions can significantly impact patients and families, and that legal regulations on this issue are sparse globally

StudiuDemențeÎncredere înaltă22.06.2026

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

This review examines how tau protein misfolding and accumulation impair blood-brain barrier integrity and vascular function in Alzheimer's disease and other tauopathies, while also exploring how cerebrovascular dysfunction promotes tau pathology. The authors highlight epigenetic and epitranscriptomic mechanisms regulating cerebrovascular integrity and tauopathy progression, with implications for therapeutic intervention.

StudiuDemențeÎncredere înaltă22.06.2026

Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease

This study examined how cognitive reserve—the brain's ability to maintain function despite Alzheimer's pathology—differs between typical and limbic-predominant subtypes of Alzheimer's disease using neuroimaging data from over 500 participants. Results showed that higher cognitive reserve predicted slower cognitive decline, with typical Alzheimer's subtype showing faster reserve deterioration than the limbic-predominant form, highlighting the importance of subtype-specific analyses in understanding disease progression.

StudiuDemențeÎncredere bună22.06.2026

Expert Consensus on Amyloid-PET Imaging for Alzheimer's Disease Diagnosis

This expert consensus addresses the clinical application of amyloid positron emission tomography (PET) as a standardized tool for early detection of Alzheimer's disease pathology, which precedes cognitive symptoms. The document recommends binary interpretation (positive/negative) of amyloid-PET results combined with clinical assessment, neuropsychological testing, and other imaging biomarkers for reliable diagnosis and treatment evaluation.

StudiuDemențeÎncredere înaltă22.06.2026

German UCSF Brain Health Assessment Shows High Sensitivity for Early Neurodegenerative Disorders

A validation study of the tablet-based UCSF Brain Health Assessment (BHA) and Brain Health Survey (BHS) in German-speaking patients found these tools highly accurate at detecting mild neurocognitive disorder and non-Alzheimer's presentations, with greater sensitivity than the Montreal Cognitive Assessment. The combined instrument achieved 95% accuracy for mild neurocognitive disorder and 96% accuracy for non-amyloid pathology cases, suggesting potential for earlier identification in primary care settings.

StudiuDemențeÎncredere înaltă22.06.2026

Anticholinergic Deprescribing Interventions for Reducing Cognitive Decline or Dementia Risk in Older Adults

This systematic review examines whether reducing anticholinergic medication burden through deprescribing interventions can prevent or slow cognitive decline in older adults. The review compares effectiveness of different deprescribing approaches (pharmacist-led, physician-led, educational) and evaluates optimal intervention duration and sustainability for maintaining cognitive health.

StudiuDemențeÎncredere bună22.06.2026

Animal-Assisted Therapy for Well-being in Alzheimer's Disease: The ELIAUT Randomized Controlled Trial

A single-blind RCT in 42 Alzheimer's patients compared animal-assisted therapy combined with cognitive stimulation versus cognitive stimulation alone. Animal-assisted therapy produced a statistically significant improvement in immediate well-being after four weeks, but did not affect cognitive function, behavioral symptoms, or depression/anxiety scores.

StudiuDemențeÎncredere înaltă22.06.2026

Hypertension and Dementia: Pathophysiology and Potential Utility of Antihypertensives in Reducing Disease Burden

This review examines hypertension as a modifiable risk factor for dementia, finding that mid-life hypertension (ages 45-64) correlates with increased cognitive decline and dementia risk, while late-life hypertension shows less consistent associations. Evidence on whether antihypertensive treatment effectively prevents dementia remains conflicting across studies, likely due to methodological differences between observational and randomized controlled trials.

StudiuDemențeÎncredere înaltă22.06.2026

Transgenic Amyloid Precursor Protein Mouse Models: Limitations as AD Models but Effective Predictors of Anti-Amyloid Therapies

APP transgenic mice model amyloid pathology in Alzheimer's disease and have successfully predicted the efficacy of anti-amyloid immunotherapies, including their adverse effects like amyloid-related imaging abnormalities (ARIA). While incomplete models of full AD pathology, these early transgenic models have accurately predicted therapeutic responses in human clinical trials that reduce amyloid and slow cognitive decline.

StudiuDemențeÎncredere bună22.06.2026

Can Speaking Multiple Languages Help Delay Alzheimer's Disease Symptoms?

This review examines evidence that bilingualism or multilingualism may increase cognitive reserve through executive control mechanisms, potentially delaying clinical dementia symptoms by 4-5 years despite ongoing neuropathology. While multilingual use does not prevent Alzheimer's disease development, it may compensate for brain changes and reduce lifetime disease burden in older adults.

StudiuDemențeÎncredere înaltă22.06.2026

Proteome-wide Analysis Identifies Cortical Proteins Associated with Cognitive Resilience in Aging and Dementia

This postmortem proteomics study of 604 older adults identified 47 cortical proteins in the dorsolateral prefrontal cortex that promote cognitive resilience across different cognitive domains, using mass spectrometry analysis while controlling for Alzheimer disease and related dementia pathologies. The protein NRN1 showed the strongest association, linked to multiple cognitive abilities including semantic memory, suggesting a potential role in protecting against dementia-related cognitive decline.